Attention Deficit Hyperactivity Disorder

Edited by Shane R. Jimerson, Ph.D.
Contributed to by the Graduate Students in the Counseling, Clinical, and School Psychology Program at the University of California, Santa Barbara.

Ongoing design and publication of this site is completed by Shane R. Jimerson, Jeff R. Klein and Angela D. Whipple.  Please forward comments regarding this site to Shane R. Jimerson.  This page was last updated 1.11.02.  © 2002

Symptoms
Epidemiology
Etiology
Assessment
Treatment
 

Authors
Shane R. Jimerson, Berkley Bowers, & Gabrielle Anderson
University of California, Santa Barbara

The authors also note the important contributions of Barbara D’Incau, Robert Ngan and Sabrina Rhee, who provided information critical to the development of this website.

Attention Deficit Hyperactivity Disorder

     Attention Deficit Hyperactivity Disorder (ADHD) is the most commonly diagnosed behavioral disorders during childhood (Tannock & Schachar, 1996; Shaywitz, Fletcher & Shaywitz, 1994; Shelton & Barkley, 1994; Kavanagh & Lyon, 1994; Barkley, 1990b).  ADHD includes a heterogeneous array of symptoms which overlaps markedly with oppositional defiant disorder, conduct disorder, affective disorders such as depression, anxiety, learning disabilities, and communication disorders.  The most common age for diagnosis is between the ages of 7 and 9, although symptoms may be apparent before the age of 3 (Cohen et. al., 1993).  According to DSM-IV-TR criteria, the onset of ADHD is before age 7, however, many individuals are not diagnosed until a later age due to the prominent expression of ADHD symptoms in the school setting. ADHD is characterized by a persistent pattern of behavioral symptoms of inattention, hyperactivity, and impulsivity (APA, 2000; Barkley, 1990a, 1990b).  Children showing behaviors that are characteristics of ADHD have been found to be highly “at-risk” for maladaptive educational and social outcomes.  Furthermore, although a child may not meet full DSM-IV criteria for ADHD, subclinical problems of inattention, impulsivity or hyperactivity may contribute to deleterious outcomes such as low reading achievement (Warner-Rogers, Taylor, Taylor & Sandberg, 2000).  It is important for the school psychologist or child clinician to provide accurate information about ADHD to children and their parents as misperceptions about the disorder, such that it is primarily a disorder of inattention or that that the ADHD child must display symptoms of both inattention and hyperactivity are common.  Controversial debates continue with regards to etiology, diagnosis and the use of pharmacological intervention for ADHD.
 
 

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DSM-IV-TR Criteria for ADHD

Source:
The Diagnostic and Statistical Manual of Mental Disorders - Fourth Edition, Text Revision (APA, 2000) lists diagnostic criteria for Attention-Deficit/Hyperactivity Disorder (p. 85-93):

A. Either (1) or (2):

(1) six (or more) of the following symptoms of inattention have persisted for at least 6 months to a degree that is maladaptive and inconsistent with developmental level:

Inattention
(a) often fails to give close attention to details or makes careless mistakes in schoolwork, work, or other activities
(b) often has difficulty sustaining attention in tasks or play activities
(c) often does not seem to listen when spoken to directly
(d) often does not follow through on instructions and fails to finish schoolwork, chores, or duties in the workplace (not due to oppositional behavior or failure to understand instructions)
(e) often has difficulty organizing tasks and activities
(f) often avoids, dislikes, or is reluctant to engage in tasks that require sustained mental effort (such as schoolwork or homework)
(g) often loses things necessary for tasks or activities (e.g., toys, school assignments, pencils, books, or tools)
(h) is often easily distracted by extraneous stimuli
(I) is often forgetful in daily activities

(2) six (or more) of the following symptoms of hyperactivity-impulsivity have persisted for at least 6 months to a degree that is maladaptive and inconsistent with developmental level:

 Hyperactivity
(a) often fidgets with hands or feet or squirms in seat
(b) often leaves seat in classroom or in other situations in which remaining seated is expected
(c) often runs about or climbs excessively in situations in which it is inappropriate (in
adolescents or adults, may be limited to subjective feelings of restlessness)
(d) often has difficulty paying or engaging in leisure activities quietly
(e) is often “on the go” or often acts as if “driven by a motor”
(f) often talks excessively

Impulsivity
(g) often blurts out answers before questions have been completed
(h) often has difficulty awaiting turn
(i) often interrupts or intrudes on others (e.g., butts into conversations or games)

B. Some hyperactive-impulsive or inattentive symptoms that caused impairment were present before age 7 years.

C. Some impairment from the symptoms is present in two or more settings (e.g., at school and at home).

D. There must be clear evidence of clinically significant impairment in social, academic, or occupational functioning.

E. The symptoms do not occur exclusively during the course of a Pervasive Developmental Disorder, Schizophrenia, or other Psychotic Disorder and are not better accounted for by another mental disorder (e.g., Mood Disorder, Anxiety Disorder, Dissociative Disorder, or a Personality Disorder).

Subtypes

Attention-Deficit/ Hyperactivity Disorder, Combined Type:
This subtype should be used if six or more symptoms of inattention and six or more symptoms of hyperactivity-impulsivity have persisted for at least 6 months to a degree that is maladaptive and inconsistent with developmental level.  Most children and adolescents with the disorder have the Combined Type.  It is not known whether the same is true for adults with the disorder.

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type:
This subtype should be used if six or more symptoms of inattention (but fewer than six symptoms of hyperactivity-impulsivity) have persisted for at least 6 months to a degree that is maladaptive and inconsistent with developmental level.  Hyperactivity may still be a significant clinical feature in many such cases, whereas other cases are more purely inattentive.

Attention-Deficit/Hyperactivity Disorder, Predominantly Hyperactive-Impulsive Type:
This subtype should be used if six or more symptoms of hyperactivity-impulsivity (but fewer than six symptoms of inattention) have persisted for at least 6 months to a degree that is maladaptive and inconsistent with developmental level.  Inattention may often still be a significant clinical feature in such cases.

Attention-Deficit/Hyperactivity Disorder Not Otherwise Specified:

This category is for disorders with prominent symptoms of inattention or hyperactivity-impulsivity that do not meet the criteria for Attention-Deficit/Hyperactivity Disorder.  Examples include:
1. Individuals whose symptoms and impairment meet the criteria for Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type but whose age of onset is 7 years or after.
2. Individuals with clinically significant impairment who present with inattention and whose symptom pattern does not meet the full criteria for the disorder but have a behavioral pattern marked by sluggishness, daydreaming, and hypoactivity.
 
 

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EPIDEMIOLOGY

     Attention deficit hyperactivity disorder is the most commonly diagnosed behavioral disorder of childhood, estimated to affect 3 to 7 percent of school-age children (American Psychiatric Association 2000; National Institute of Health, 1998).  Increases in identification during the school-age years may be a factor of the school environment rather than increases in the actual incidences.  More specifically, behavioral symptoms of ADHD (i.e., easily distracted, difficulty sustaining attention in tasks) are more often observed in classroom settings where formal structure is warranted.  Thus, children are more likely to be referred for an ADHD diagnosis during the school-age years rather than the pre-school years when certain behavioral norms are expected in the elementary classroom.  More often than not, symptoms of this disorder are evident beginning in early childhood and extend into adulthood.  Indeed, it has been reported that 50 percent of children diagnosed with ADHD as preschoolers will either receive a similar diagnosis at a later age (Campbell, 1990) and/or continue to exhibit symptoms of this disorder into adulthood (Barkley, Fischer et.al., 1990; Gittelman et.al., 1985; Weiss & Hechtman, 1993). Developmentally the symptoms of ADHD typically attenuate or change in form as one matures and grows older, though the severity and extensity of problems may remain (American Psychiatric Association, 2000; Whalen & Henker, 1998).
     The number of boys diagnosed with ADHD outnumber girls by at least 4 to 1.  The higher ratio of males in clinic samples may be due to selective referral, rather than actual incidence.  Furthermore, females are more likely to exhibit internalizing symptoms that involve mood, affect and emotion, whereas males usually display more externalizing symptoms such as aggressive and antisocial behaviors.  Thus referrals initiated from the school environment are more likely to be due to overt or disruptive behavior, symptoms found more often in males with this disorder.  Children who exhibit the Predominantly Inattentive Type are more likely to be placed in special education classes for students with learning disabilities despite that as a group they do not display significantly greater learning deficits than children with the Combined or Predominantly Hyperactive-Impulsive Types.  Furthermore, children who exhibit the Combined and Hyperactivity-Impulsive Types are more likely to be placed in special education classrooms for children with emotional and behavioral disorders  (Warner-Rogers, Taylor, Taylor, & Sandberg, 2000).
 Warner-Rogers, Taylor, Taylor, and Sandberg (2000) redressed the lack of research focusing specifically on children who exhibit inattentive behavior through an large, community-based epidemiological study of seven year old boys.  Comparisons were made between the developmental functioning, social, and environmental backgrounds of children with pure inattentive behavior to that of children with pure overactive behavior and combined problems of inattentive and overactive behavior.  The authors found that children with pure inattentive behavior were more likely to have general cognitive delays, especially in the area of language development, and were more likely to come from families where the father was of low occupational status.
     This study underscores the importance for educators, clinicians, and researchers to improve identification methods for children displaying the Predominantly Inattentive Type.  Although purely inattentive children did not exhibit the magnitude of disruptive behavior that the purely overactive or Combined Type children did, inattentive behavior was highly associated with adjustment problems in the classroom such as having reading impairments, possessing low self-esteem, and needing directions repeated (Warner-Rogers, Taylor, Taylor & Sandberg, 2000).
     Co-morbidity of ADHD with conduct disorder (50  percent; Biederman et. al., 1991), oppositional-defiant behavior, anxiety disorders, speech and language disorders (78  percent; Baker & Cantwell, 1992), and learning disabilities (LD) (41-70 percent; Holborow & Berry, 1986; Mayes, Calhoun & Crowell, 2000) is extremely high.  Estimates of the incidence of school-age children with partial ADHD syndrome and one or more other problems present (i.e., anxiety, depression, etc.) are 5 to 10 percent (www.chadd.org/facts).  Comorbidity appears to be more common in younger than in older children (Bird et. al., 1993; Russo & Beidel, 1994).
     Mayes, Calhoun, and Crowell (2000) explored the overlap between ADHD and learning disabilities in a clinical sample of 8 to 16 year olds.  The authors found that a LD was present in 70 percent of the children with ADHD.  Furthermore, a LD in written expression was twice as common (65 percent) as a LD in reading, math or spelling.  No previous research studies examining the prevalence of LD in children with ADHD assessed for LD in written expression. Furthermore, children with both a LD and ADHD had more severe learning problems than children who had a LD but not ADHD as well as had more severe attention problems than children with ADHD but not a LD.  Based on their observation that children with ADHD who did not meet full criteria for a LD still experienced learning difficulties, the authors conclude that learning and attention problems are best conceptualized as existing on a continuum where they usually are interrelated and coexist.
     The symptoms of this disorder are closely tied to behavioral difficulties.  And as a result, it has been documented that about 40 percent of referrals to child guidance clinics are associated with children diagnosed with this disorder (Barkley, 1990).  Over 60 percent of adolescents with ADHD have been documented to be defiant in comparison to 11 percent of the non-ADHD population (Barkley, Fischer, Edelbrock & Smallish, 1990).  As adults, it has been estimated that 33 percent will not complete high school, with only 5 percent completing a college degree (Barkley, Fischer, et. al., 1990).  Almost 1 in 4 of these individuals is likely to develop chronic maladaptive patterns such as substance abuse, occupational instability, and interpersonal difficulties (Barkley, Fischer, et. al., 1990).  About one-third of this population is estimated to be resilient, meaning they find adaptive means to cope with the disorder (Barkley, 1990).
     Gingerich, Turnock, Litfin, and Rosen (1998) considered the epidemiology of diverse populations and ADHD.  The authors stress the importance of including diversity variables such as ethnicity, age, gender, and SES in the assessment, diagnosis, and intervention strategies of ADHD.  Cross-cultural comparison of hyperactive behavior must be understood and examined with caution as cultural factors may influence both the demonstration of the disorder as well as the approach to intervention strategies.  These diversity variables may contribute to inappropriate diagnosis as expected behavioral norms may fluctuate in these various groups. A 1999 study in the Journal of the American Academy of Child and Adolescent Psychiatry addressed the gender differences in the diagnosis of ADHD. The authors suggest that the disorder frequently goes undiagnosed in girls because they are less likely to behave disruptively, which is one of the most common signs of the disorder.  The study included 140 girls with ADHD and 122 girls who did not have ADHD, ranging in age from 6 to 18 years old.  Results of this study imply that if the core problem of ADHD is redefined from a behavior disorder to the issue of inattention, then it is likely that the number of girls identified will increase.
     Attention-deficit/hyperactivity disorder is one of the most prevalent childhood disturbances in the United States, affecting upward of 400 million children and adolescents. ADHD has received much publicity in recent years and professionals should clarify misunderstandings when working with children and their families.  Children with ADHD may have pronounced difficulties and impairments resulting from the disorder across multiple settings.  They may also experience long-term adverse effects on academic performance, vocational success, social-emotional development and peer relations.  Males are diagnosed with ADHD at approximately three times the rate of females which may be due the Combined and Predominantly Hyperactive-Impulsive forms of the disorder being more common in males.  There is no conclusive evidence of the causes of this disorder, thus extensive assessment measures should include various settings as well as informants in order to understand the multiple factors that may contribute to the symptoms.  Given the overlap of ADHD with oppositional defiant disorder, conduct disorder, antisocial personality traits, and learning disabilities, psychologists need to assess related domains of functioning when addressing a referral question regarding ADHD.  Subclinical problems such as learning difficulties, hyperactivity, and attention problems should also be addressed when planning treatment interventions. Recent studies reveal that there are wide variations in the diagnosis of the disorder, resulting in under and over identification of ADHD within certain populations, thus environmental and socio-cultural variables need to be considered during assessment of the behavioral symptoms common in ADHD.
 
 

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I.  ETIOLOGY

     The familial incidence of ADHD has long been noted. Early investigations centered around biological hypotheses and “Minimal Brain Dysfunction” was postulated in explaining the origin of the disorder.  Following World War II, pediatricians, neurologists, and child psychiatrists observed that brain-damaged children were often hyperactive, inattentive, had learning difficulties, and displayed a wide variety of behavior problems. This led to the original diagnostic concept of “minimal brain damage.”  However, subsequent large epidemiological studies of grossly brain-damaged children did not support a link with excessive hyperactivity nor did more recent imaging studies find evidence of gross brain damage in ADHD children.
     Over time, the various characteristics including hyperkinesis/hyperactivity, inattention/distractibility, and impulsive responding became the focus of research in etiology, assessment, and treatment.  Whether or not attentional deficits are, in fact, a hallmark of this disorder is currently debated.  The great variability in symptomology, prognosis, and comorbidity has made definite etiologic determinants elusive. As a result, it has captured the interest of clinicians and researchers from many different disciplines.  Currently researchers are also investigating and comparing the etiologies of different ADHD subtypes which indicate that ADHD is a heterogeneous disorder.  Moreover, an understanding of the etiology of ADHD has important implications for treatment procedures.  Current hypotheses involve a complex transactional model which links genetic, biological, familial, cognitive/ neurological, psychosocial, and developmental contributors.  The following sections of this paper will provide information and current research regarding various etiological factors and their associations with ADHD.

Genetic Contributors:

     Research evidence suggests that ADHD is a trait which is highly hereditary in nature, making heredity one of the most well-substantiated etiologies for ADHD (Barkley, 1997).  Consequently genetic research has contributed to these studies in order to explain familiality, heritability, mode of transmission, and gene locations (Tannock, 1998).  Twin studies have provided genetic researchers the opportunity to explore genetic as well as shared and non-shared environmental factors in the identification of ADHD.
     Research has shown that if a parent has ADHD, the risk to the offspring is 57 percent.  As evidenced by recent twin studies, the average heritability is .80 for symptoms of ADHD, suggesting a strong genetic contribution (Barkley, 1997).  Sprich, Biederman, Crawford, Mundy and Faraone (2000) lent additional support to the genetic hypothesis for ADHD etiology through their study examining the rates of ADHD and associated disorders in the first-degree biological relatives of ADHD children and adolescents.  The authors found that 18% of the biological parents of ADHD youths had ADHD compared to 6% of the adoptive parents of ADHD youths and 3% of the biological parents of the non-ADHD control youths.  As the rate of ADHD in adoptive parents of adoptees with ADHD did not differ significantly from the rate found in the biological parents of the control subjects, the researchers conclude that there is no increased risk for ADHD amongst the adoptive parents of adopted ADHD youths.  Furthermore, significantly higher rates of mood and anxiety disorders were found in the biological parents of ADHD youths than in the adoptive parents of ADHD youths.  The authors suggest that these other psychiatric disorders are manifestations of the same genes that influence ADHD rather than parental disorders resulting from the stress of raising a child who has ADHD.
     In a review of molecular genetic studies of AHD, Faraone (2000) proposes that ADHD comprises several disorders having different genetic and nongenetic etiologies rather than a single, unitary disorder.  This proposition is supported by inconsistent results from molecular genetic studies such as those investigating the influence of the dopamine transporter gene (DAT) and the dopamine D4 receptor gene (DRD4) on susceptibility to ADHD (Biederman & Spencer; Faraone, 2000).  Faraone highlights two other clinical features, psychiatric comorbidity and long-term outcome, as evidence for the genetic heterogeneity of ADHD.
Faraone and his colleagues tested competing hypotheses about the comorbidity of ADHD with other disorders and concluded that there appear to be two types of ADHD families.  There are families in which ADHD occurs with bipolar disorder and/or conduct disorder and there are families in which ADHD occurs without bipolar disorder or conduct disorder.  Although ADHD and major depression were found to share common familial vulnerabilities, the researchers were unable to distinguish subforms of ADHD based upon the presence of major depression in the family.  Hence, in contrast to bipolar disorder and conduct disorder, major depression appeared to be a phenotypic rather than a genetic marker of heterogeneity in ADHD.  Anxiety and learning disorders showed weak associations with ADHD in the families of this study.  However, the authors stress the need for more investigation in order to make conclusions about whether these disorders share genetic causes with ADHD.
     As long-term outcome may have further implicates for genetic heterogeneity, Faraone cites evidence for the stronger influence of genes on persistent ADHD than on remitting ADHD.  Faraone, Biederman, and Monuteaux (2000) found that the prevalence of ADHD in parents of youths who continued to meet diagnostic criteria for ADHD in mid-adolescence was 16.3%  compared to a 10.8% prevalence of ADHD  in the parents of youth whose ADHD had remitted by mid-adolescence.  The prevalence in their siblings was 24.4% and 4.6%, respectively.  Faraone (2000) interprets the data as suggesting that children and adolescents with persistent ADHD have a more familial form of the disorder than those whose ADHD remits by mid-adolescence.
     Citing molecular biological studies of genes affecting dopamine and serotonin as contributors to ADHD and Tourette Syndrome, Comings (1997) considers the two disorders as hereditary spectrum disorders.  This work is said to supplement twin studies which have found that genetic factors play a significant role in both ADHD and Tourette Syndrome, implying a polygenetic inheritance pattern.  The two conditions are best described as spectrum disorders because of their appearance in multiple family members as well as their association with several comorbid disorders including drug and alcohol abuse and conduct disorder.  Sherman and colleagues found greater concordance for monozygotic than dizygotic twins in both teachers’ and mothers’ ratings, providing evidence for the genetic contribution to expression of ADHD (Sherman et.al., 1997). Twin studies can tell us as much about environmental contributions as they do about genetic factors affecting the expression of a trait.  Across the twin studies conducted to date, the results have been reasonably consistent in demonstrating that the shared environment contributes little, if any, explanation to individual differences in the trait underlying ADHD (hyperactive-impulsive-inattentive), typically accounting for less than 5 percent of the variance among individuals.  In a study by Levy, Hay, McStephen, Wood, and Waldman (1997) shared environmental factors included social class, family educational/occupational status, general home environment, family nutrition, toxins that may be present in the home environment (i.e., lead), and parental and child-rearing characteristics.

Biological Contributors:

     The potentially causative factors associated with ADHD that have received the most research support are biological in nature; that is, they are known to be related to or to have a direct effect on brain development and/or functioning (Barkley, 1997).  Barkley dismisses theories of social and dietary causes of ADHD as having weak support, and instead focuses on the much larger body of empirical evidence which supports the association of biological vulnerability toward poor inhibitory control and ADHD.  Children with pervasive ADHD showed the least inhibitory control and greatest variability of responses compared with a control group (Oosterlaan & Sergeant, 1996).  In addition, MRI scans have shown distinct physiological differences in brain regions between ADHD and control children (Barkley, 1997).
     Pregnancy, delivery and infancy complications (PDIC’s) have been studied to determine correlates and/or predictors of ADHD.  Milberger, Biederman, Faraone, and Guite (1997) found a positive association between ADHD and PDIC’s using linear and logistic regression models in their study.  In addition, very low birthweight children have been found to have an increased prevalence of inattention and hyperactivity; 23 percent of very low birthweight children met research diagnostic criteria for ADHD in contrast to 6 percent of normal birthweight peers (Bottin, Powls, Cooke, and Marlow, 1997).
Milberger et al. (1996) investigated the role of maternal smoking during pregnancy in the etiology of 6-17 year old boys with ADHD found that 22% of the ADHD children had a maternal history of smoking during pregnancy, compared with 8% of the comparison non-ADHD Subjects. This finding remained significant after adjustment for SES, parental IQ, and parental ADHD status.
     Hill, Lowers, and Locke-Wellman (2000) explored the question of whether maternal cigarette smoking or drinking during pregnancy places the child at risk for ADHD.  The longitudinal study examined the association between prenatal exposure to cigarettes and alcohol for the etiology of childhood psychopathology including ADHD.  The findings revealed that prenatal exposure to alcohol was significantly associated with the presence of ADHD although, after controlling for SES and parental antisocial personality disorder, this finding did not remain significant.  Furthermore, the findings did not confirm the association between cigarette use and ADHD reported by Milberger et al. (1996).

Family Contributors:

     Research encompassing family contributors to ADHD has included studies of parental psychopathology, parenting styles, and parent-child interactions.  Viewing family factors and their relation to ADHD through the perspective of the transactional model has implications for both the etiology and treatment of the disorder.  The transactional model proposes that maladaptive behaviors and/or disorders such as ADHD can be viewed in terms of the “reciprocal effects of children on their environmental contexts and contexts on children” (Sameroff & Chandler, 1975; Sameroff & Fiese, 1988).
Nigg & Hinshaw (1998) highlighted two significant findings in their examination of the role of specific parental characteristics in relation to ADHD; 1) boys with ADHD were more likely to have mothers with a major depressive episode and/or marked anxiety symptoms in the past year, and fathers with a childhood history of ADHD, and 2) boys with comorbid ADHD and Oppositional Defiant or Conduct Disorder had fathers with lower Agreeableness, higher Neuroticism, and more likelihood of having Generalized Anxiety Disorder.
     Pfiffner, McBurnett, Lahey, Loeber, Green, Frick, and Rathouz (1999) examined the relationship of parental psychopathology to similar forms of comorbid psychopathology in children with ADHD (Pfiffner et.al., 1999).  Their findings suggest that type of child psychopathology accompanying ADHD (internalizing and/or externalizing) is concurrently predicted by the same type of parental psychopathology.  This finding contrasts with theories that comorbidity is simply a reflection of more severe psychopathology among children with ADHD and instead supports specific modes of familial transmission.
Johnston and Freeman (1997) assert that the social context within which ADHD behaviors are displayed is an important etiological consideration.  In this study of children with and without ADHD and the parent-child relationship, parents of ADHD children viewed the disorder as primarily internally caused, beyond the child’s control, and as relatively stable over time.  These beliefs are consistent with a neurobiological etiology of ADHD.
      Weinstein, Apfel, and Weinstein (1998) examined personality traits and background variables of mothers and children with and without ADHD.  Mothers with ADHD had elevated scores on Neuroticism and Conscientiousness.  Furthermore, neuropsychiatric disorders, atypical sexual events, and familial alcoholism were found with more frequency in the group with ADHD mothers and ADHD children.
     Woodward, Dowdney, and Taylor (1997) compared child and family factors in clinically referred boys with ADHD and those not referred.  Results suggest that clinic referral is more likely in children with hyperactivity when the parent is having difficulty coping and the child is experiencing greater peer and emotional problems in school.
     White (1999) points out the confluence of findings from studies examining parent-child interactions suggests that parents of ADHD children tend to provide more impulse-control directions, encouragement, and disapproval than parents of non-ADHD children.  Research has indicated that these parent behaviors persist after the child’s behavior improves.  Thus, it is unclear whether these parental behaviors are responses to the behavior problems of the child.  The parent-child relationship may be viewed through a transactional lens as an on-going, reciprocal transaction.  For example, raising a child with ADHD may continuously stress the parent and, therefore, affect the quality of the parent-child relationship, potentially impacting the child’s behavior (White, 1999).
     Viewing these family factors and ADHD through the transactional model has important implications for intervention strategies. Treatment plans might address the familial context through interventions such as parent-skills training, coping techniques.  in order to modify individual behaviors and contextual factors which may be contributing to the increased rate of observable characteristics of ADHD.

Cognitive and Neurological Contributors:

      The early onset of the symptoms in ADHD and their relatively persistent nature over time, their association with other developmental disorders believed to arise from neurological development or impairment (i.e., learning disabilities, language disorders, motor abnormalities, and IQ), their significant relationship to peri and postnatal adversities, and their relatively dramatic improvement by stimulant medication have served to repeatedly focus research attention on possible causal neurodevelopmental factors (Barkley, 1997).
      Biederman and Spencer (1999) reviewed neurobiological and pharmacological research in order to investigate the hypothesis that a dysregulation of the central noradrenergic networks is responsible for the pathophysiology of ADHD.  The noradrenergic system is believed to modulate higher cortical functions including attention, especially the maintenance of arousal, a cognitive function that is believed to be deficient in ADHD. Pharamocological studies provide strong evidence that drugs with noradrenergic and dopaminergic pharmacological profiles can be used to effectively treat ADHD.  The authors conclude, “Although there is no single pathophysiologic profile of ADHD, much data do implicate dysfunction in the fronto-subcortical pathways that control attention and motor behavior.” Researchers underscore the need for further research to confirm empirical evidence which suggests that norepinephrine may play a key role in the attentional and inhibitory abilities of the prefrontal cortex (Biederman & Spencer, 1999; White, 1999).
      Max, Arndt, Castillo, Bokura, Lindgren, Smith, Sato, and Mattheis (1998) examined ADHD symptomatology and sequelae after traumatic brain injury (TBI) in children and adolescents.  A significant correlation was found for ADHD symptomalogy and a measure of family dysfunction when family psychiatry history, SES, and severity of TBI were controlled.  Results indicate that changes in ADHD symptoms in the first two years after TBI was significantly related to the severity of TBI, suggesting implications for a neurological basis of ADHD.
      Sheppard, Bradshaw, Purcell, and Pantelis (1999) suggest that the high level of comorbidity of both OCD and ADHD in Tourette’s suggests that the gene responsible for Tourette’s Syndrome may at least be responsible for an increased susceptibility to these two disorders.  The authors suggest this may be due to the neuropathological overlap and/or a neurochemical imbalance.  This examination of the comorbidity among disorders is not meant to discount the idea that these disorders can exist on their own with their own etiologies.
      The broad definition of executive function has guided current research towards the testing of various interpretations of impulsiveness/response inhibition in ADHD.  Such models include: An underlying deficit in a central act of control; a dysfunction in the energetical/state-regulation of motor control; and a deviant cognitive style designed to reduce the subjective experience of delay (Tannock, 1998).  The following studies address the executive function process in individuals with ADHD.
     Carte, Nigg, and Hinshaw (1996) used a neuropsychological battery to measure executive functioning in boys with and without ADHD.  When tasks required a slow pace, selective attention demand, and rapid automatic naming, subjects with ADHD performed more poorly than controls.  Results are consistent with hypothesized deficits for ADHD in organization and planning, possibly mediated by frontal systems, as well as with the cognitive model of response organization.
      Nigg (1999) considered the neuropsychological executive functions of behavioral or response inhibitions as an etiological factor in ADHD in a replication study.  Results indicate that deficits in motor inhibition processes are associated with the DSM-IV ADHD Combined Type.  However, whether the response inhibition is a frontal, behavioral inhibition system or some other inhibition process remains to be explored.  While recent advances in structural and functional imaging techniques of the brain are leading to a new understanding of disorders such as ADHD, functional studies are necessary to determine which anatomical abnormalities have functional sequelae, as well as to demonstrate abnormal cognitive processes inferred from such neuropsychological studies (Tannock, 1998).

Psychosocial Contributors:

     Sandberg and Garralda (1996) state that a number of psychosocial factors are associated with the development of ADHD although it seems unlikely that a direct causal relationship exists in this case.  Factors that are associated with ADHD include social conditions, family stability and marital discord, psychiatric disorder in parents, parenting styles, and the quality of family interactions.  In particular, they highlight social conditions and maternal depression as highly correlated with ADHD.
     Another factor that is well associated with ADHD in the research literature is the relationship between ADHD and temperament (White, 1999).  A high level of activity or hyperactivity is perhaps the most salient temperamental trait of ADHD children.  These children are generally markedly distractible and impulsive and, therefore, tend to be most readily diagnosed due to their behavior frustrating teachers and caretakers.  One popular explanation offered to explain the impulsivity that is characteristic of individuals with ADHD is that they are constitutionally underaroused and thus seek external stimulation.  This hypothesis is supported by empirical evidence suggesting that children and adolescents with ADHD are more likely than their non-ADHD peers to engage in risky behavior.  However, these youths not only tend to seek out arousing experiences, they also have lower levels of inhibitory control when presented with high levels of stimulation (White, 1999).
     Temperamental difficulties related to disinhibition are considered to relatively remain stable throughout the lifespan of the individual with ADHD (White, 1999).  In a study mentioned earlier by Oosterlaan and Sergeant (1996), ADHD children demonstrated poorer inhibitory control and a slower inhibitory process than control group children in response to a stop signal task.  It is interesting to note that aggressive children showed a lack of inhibitory control and a slower inhibitory process that were similar to the ADHD children.
     Hinshaw, Zupan, Simmel, Nigg, and Melnick, (1997) examined the predictive power of behavioral, internalizing, and familial variables with respect to peer status in boys with and without ADHD.  Aggression, covert behavior, and authoritative parenting beliefs were the independent predictors of both negative peer status and peer social preference.  Authoritative parenting beliefs were stronger predictors in peer status in children with ADHD than in comparison youth.
     Harvey (1998) studied how parent’s employment influences conduct problems in children with ADHD.  Results demonstrated that time spent in employment indirectly affected childcare workload and parental well-being for mothers only.  The more time that mothers spent at work, the lighter the childcare workload, which was then related to mothers’ greater parenting well-being and fewer conduct problems for the children.
     The transactional model can again be used in the domain of psychosocial contributors to explain the interacting effects of the individual with ADHD and the given context.  While the transactional model may not explain the underlying causes of ADHD, it does offer explanations as to how the individual and the environment effect one another in a reciprocal manner.  For example, a child’s temperament may solicit negative responses from adult caretakers and peers, whose responses may, in turn, contribute to future behavior problems. Consequently, throughout the individual’s growth and development over time, their unique ADHD symptoms may fluctuate depending on the surrounding environment and their interactions with it.

Developmental Contributors:

     Combining several of the previously discussed etiological factors of ADHD, Barkley suggests that ADHD is a “developmental disorder of behavioral inhibition that impairs the development of self-regulation (executive functioning) and is not, as its name implies, chiefly a disorder of attention” (Barkley, 1997).  Barkley defends this idea by suggesting that not all forms of self-regulation are fully covert or internalized in the early school-age years and may not be so until early adolescence.  Thus as one develops, their ability to control behavior shifts from an external governance to an internal regulation.
     The understanding of the development of ADHD symptomatology is important because of the apparent relationships between these symptoms and subsequent development of behavior problems and educational, occupational, and interpersonal maladaptions.  Olson (1996) states “behavior deviance is the product of a continuous, dynamic interplay between qualities that individual children bring to their social interactions and characteristics of the immediate caregiving environment and its broader social-ecological context”.
     From this perspective, risk factors, vulnerability factors, and resiliency factors are all essential in the understanding of the eventual outcome of behavioral disorders.  In the research literature, positive outcomes for ADHD children are associated with higher IQs, fewer health problems, an internal locus of control, physical health, high self-esteem, positive coping skills, achievement orientation, and social skills (White, 1999). Although these characteristics may serve as protective factors for ADHD children, low levels of these same traits characterize the disorder itself.  ADHD children are more likely than non-ADHD children to have inferior social skills, lower achievement orientation, and an external locus of control.  Hence, the less ADHD symptoms that the child has, the more positive his or her trajectory is likely to be (White, 1999).  Furthermore, at the family level, high levels of cohesion, support, and warmth as well as higher SES and two-parent families with fewer children are predictors of positive, long-term outcomes for ADHD children (Hechtman, 1996).
      Seidman, Biederman, Faraone, Weber, and Oullette (1997) extended studies on developmental processes in the neurophysical investigation of ADHD.  Related to developmental progression, neuropsychological test performance generally improved with age for both the ADHD and non-impaired samples.  The youngest participants with ADHD had the lowest performance scores for al groups.  Significant neuropsychological impairment continued to be present for the ADHD group relative to controls, which contrasts with the idea that children “outgrow” ADHD in the adolescent or adult years.
     Nolan, Volpe, Gadow, and Sprafkin (1999) addressed the developmental approach to the diagnosis of ADHD by examining age, gender, and comorbidity differences in the three different subtypes.  Results indicate that hyperactive/impulsive behavior was more common in adolescents.  Subjects who exhibited symptoms of both inattention and hyperactivity/impulsivity were more likely to show behaviors characteristics of oppositional and conduct disorders, than those who were only considered inattentive.
 

II.  DEVELOPMENTAL APPROACH

     The developmental approach is a contemporary framework for understanding psychopathology.  A fundamental tenet behind this approach includes descriptions of developmental deviations in relation to normal patterns of functioning.  Manifestation of psychopathology is the result of life-long interactions between genetics, biological dispositions and the social environment.  Two undergirding principles within the developmental psychopathology framework are equifinality, which refers to the multiple paths that can lead to the same outcome, and multifinality, which suggests there are various possible outcomes to similar developmental pathways.  Thus, according to this paradigm, an ecological and transactional approach, which takes into account the influence of many factors (for example, genetic, biological, social, and familial) throughout the developmental process, would best be able to explain eventual outcome.  It is extremely difficult to tease apart the factors contributing to a specific trajectory.  White (1999) summarizes, “A complex cluster of biological, psychological and situational factors appear to be related to the etiology and symptom presentation of ADHD.”
     Developmental psychopathology is a product of ontogenetic, biochemical, genetic, biological, physiological, cognitive, social-cognitive, socioemotional, environmental, cultural, and societal influences on behavior (Cicchetti and Cohen, 1995).  When considering Attention Deficit Hyperactivity Disorder (ADHD), the multiple proposed causal pathways and the inability of researchers to empirically account for a single cause for this disorder is indicative of the notion of equifinality.  Further, the large number of identified symptoms (of which relatively few are necessary for an ADHD diagnosis) will inevitably result in a wide variety of profiles that are given the ADHD label.  The heterogeneity of the disorder appears to be consistent with the multifinality tenet of the developmental approach.  A developmental-systems perspective will need to take into account the normal variation in development (e.g., in different domains within an individual as well as variation in one domain of development between individuals).  This will require the use of multiple measures, assessment of more than one domain of development, and the study of various age-groups of children (Tannock, 1998).
      Etiology of ADHD remains unclear, although multiple factors such as genetic susceptibility, biochemical dysfunction, and environmental interactions have been proposed.  Accordingly, the various etiological models have different implications for diagnostic assessment, treatment, and management.
      Extensive evidence exists which supports a heritability factor for attention deficit hyperactivity disorder, with greater risk of the disorder being found among family members.  Biological and neuroanatomical studies involving neuro-imaging have measured cerebral blood flow as well as cerebral glucose metabolism and scanning techniques have documented physical abnormalities in particular brain regions, especially the frontal lobes, for adults and children with ADHD.  In addition, pregnancy and infancy complications can be an influencing factor.  Low birthweight children have been found to be particularly at risk for ADHD and other learning disorders.  Current attempts focus more on a framework that incorporates a multiplicity of causal factors underlying ADHD.  The developmental perspective asserts the interactional nature of the organism with environmental contexts.  Although the preponderance of evidence supports a genetic-neurobiological etiology, the developmental perspective has emphasized the interactional nature of the organism with environmental contexts.  Neuropsychological testing has suggested that while the developmental trajectory for ADHD is linear, normal brain maturation processes may attenuate symptoms over time, although ADHD is generally believed to be a lifelong disorder.  Furthermore, the manifestation of ADHD symptomatology may change over time.  For example, hyperactivity in childhood evolve into a subjective sense of restlessness in adolescence.  Considering the heterogeneity of children diagnosed with ADHD, such diverse etiological evidence may facilitate an enhanced diagnostic structure with greater specificity.  That is, there may be distinct alternative pathways towards a diagnosis of ADHD.
 

III. ADHD WEBSITES

Top Ten Websites

www.aap.org/policy/ac0002.html
Title: Diagnosis and Evaluation of the Child with Attention-Deficit/Hyperactivity Disorder (AC0002)
Author: American Academy of Pediatrics
 This website features practice guidelines for the assessment, diagnosis, and treatment of school-aged children with attention-deficit/hyperactivity disorder (ADHD).  Although these guidelines are intended for primary care clinicians working in primary care settings, mental health care professionals, educators, and students may find this site informative, as the youth’s primary care provider is an integral member of the evaluation team.  The Committee on Quality Improvement of the American Academy of Pediatrics selected a panel of experts in pediatrics, neurology, psychology, child psychiatry, development, epidemiology, and education in order to develop an evidence base of research literature, which was used to formulate these recommendations.  Major themes include child and family assessment, school assessment, and comorbidity.  These practice guidelines were published in the May 2000 edition of Pediatrics.

www.add.about.com/health/add/ OR www.add.miningco.com/health/add/
Title: Attention Deficit Disorder
 Both addresses will link you to a website containing a wide variety of practical resources for ADHD.  The website is also an excellent search engine for ADHD research abstracts/summaries (e.g., the NIMH Nultiodal Treatment Study of Children with Attention Deficit Hyperactivity Disorder) and journal articles. For example, there are links to research journals such as the Journal of Abnormal Child Psychology as well as to abstracts from the National Institute of Health (NIH) conference.  The website also contains other ADHD topics for parents such as Ritalin, the presentation of ADHD at different age levels, special education, advocates/attorneys, and book reviews.  One unique feature of this website is summaries of ADHD subtopics in Spanish.  This may be a good resource for Spanish-speaking parents.

www.addinschool.com
 This website provides interventions and resources for parents and education professionals.  Practical tips and advice are presented separately for elementary and middle/high school level students.  Examples of topics include: Classroom set-up and ADHD students, presenting lessons to ADHD students, giving tests to ADHD students, improving the socials skills of ADHD students, assisting the ADHD students with organization, increasing the on-task behavior of ADHD students, and dealing with the impulsive behaviors of ADHD students.  This is website may serve as a valuable resource for parents and education professionals seeking accommodations for ADHD students that can be incorporated into the everyday classroom routine without a great deal of effort.

www.addwarehouse.com
This website provides abundant information on assessment and evaluation procedures currently used by school psychologists and other professionals. The ADDwarehouse website provides the most current information available on attention deficit disorders.  Teachers, health-care professionals, parents, and children and adults with ADD can get information about a broad selection of products and quality service. Qualified professionals can order assessment measures through this website such as the BASC, Conners Rating Scale, ACTeRS, All Child and Adolescent Symptom Inventories, Attention-Deficit Scales for Adults, The Continuous Performance Test products, Gordon Diagnostic System, and T.O.V.A.

www.chadd.org
Title: Children and Adults with Attention Deficit Disorders
Written by parent advocates for parents, this web site contains an introduction to the disorder ADHD, an empirically sound discussion of both helpful and controversial treatments, and behavioral interventions for parents who have or believe they may have a child with ADHD.  CHADD is a national organization, which has local chapters in many cities.  This website provides current information on medical, scientific, educational and advocacy issues.  The literature includes position papers, government publications, current research studies (mostly on treatment issues), fact sheets (e.g., legal rights for children with ADD), ADD in the media, and current events pertaining the organization.  CHADD also has a quarterly magazine for people with ADHD.

www.kidsource.com/LDA-CA/ADD_WO.html
Title: Attention Deficit Disorder Without Hyperactivity: ADHD, Predominantly Inattentive Type
Authors: Jennifer Wheeler, M.A., and Caryn L.  Carlson, Ph.D. of the University of Texas at Austin
Source: The Learning Disabilities Association of California
 This website provides a detailed description of Attention Deficit Disorder Without Hyperactivity, Predominantly Inattentive Type (ADHD, IA).  The authors begin with a discussion of ADHD, IA as a valid DSM diagnostic category.  The contents also discuss etiology, activity level, accompanying disorders, peer relationships, school performance, and treatment as they relate to ADHD, IA.  This article was found on the Kid Source Online database.  Kid Source Online (www.kidsource.com/) advertises itself as “the source for in depth and timely education and healthcare information that will make a difference in the lives of parents and their children.”

www.medscape.com
Title: Attention Deficit Hyperactivity Disorder
 Medscape is an excellent resource for the latest medical research on the etiology of ADHD as well as other ADHD subtopics.  Searches can be limited specific dates including the last twelve months.  The database includes articles, conference summaries, treatment updates, clinical management modules, practice guidelines, and textbooks. Searches can also be made on other databases such as MEDLINE, News, Drugs by Name, and Drugs by Disease. After filling out a brief online survey, use of the database is free.

www.schoolpsychology.net/p_01.html
Title: School Psychology Resources Online
The School Psychology Resources Online website allows psychologists, parents, and educators to research a variety of developmental psychopathological disorders including ADHD.  Example search results for ADHD included reviews and links to websites such as diagnosis and evaluation recommendations from the American Academy of Pediatrics, a Scientific American article by Russell Barkley, and school-based ADHD accommodations for a 504 plan.

www.scientificamerican.com/1998/0998issue/0998barkley.html
Title: Attention Deficit Hyperactivity Disorder
Author: Russell Barkley- Director of Psychology and Professor of psychiatry and neurology at the University of Massachusetts Medical Center.  He has numerous publications, including two books: ADHD and the Nature of Self-Control (1997) and Attention Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment (1998).
This website provides various etiological information with an emphasis on a neurological basis.  General topics include: Search for a cause of ADHD, From
genes to behavior, Prescribing self-control, Diagnosing ADHD, A psychological model of ADHD, Illustrations of the brain, Further reading, and Related links.  More specifically, in the search for a cause section there is a focus on neurological imaging techniques and genetics.  Information also includes discussions about the different regions of the brain, as well as genetic research focusing on heritability and twin studies.  The main premise of this website is impaired behavioral inhibition and self-control are the central deficits in ADHD.

www.surgeongeneral.gov/library/mentalhealth/chapter3/sec4.html
Title: Mental Health: A Report of the Surgeon General-Chapter 3
Source: The United States Surgeon General
This website is a subsection of the U.S. Surgeon General’s mental health report outlines the following ADHD subtopics: Prevalence, causes (etiology), pharmacological treatment, psychostimulant treatment, psychosocial treatment, behavioral approaches to treatment, Cognitive-Behavioral Therapy, psychoeducation, multimodal treatments, treatment controversies, overprescription of stimulants, and safety of long-term stimulant use.

OTHER WORLD WIDE WEBITES ON ADHD

www.aacap.org/clinical/adhdsum.htm
Title: Summary of the Practice Parameters for the Assessment and Treatment of Children, Adolescents, and Adults with Attention-Deficit/Hyperactivity Disorder
Author: American Academy of Child and Adolescent Psychiatry
This website makes specific recommendations for clinicians faced with the assessment, differential diagnosis, and treatment of children, adolescents, and adults who present with symptoms of ADHD.  Specific recommendations are based on an extensive review of the scientific literature and clinical consensus among experts on ADHD. Comorbidity with other disorders is also described.

www.addclinic.com
 The website provides links to ADHD resources such as support groups and an internet search engine for ADHD.  Many of the websites featured on the homepage advertise alternative treatment products and services for ADHD (e.g., dietary supplements instead of stimulants).

www.add.org
Title:  National Attention Deficit Disorder Association
 The National Attention Deficit Disorder Association is a nonprofit organization, built around the needs of adults and young adults with ADHD.  Information on research, treatment, books on ADD, family issues, legal issues, support groups and personal interviews, and weblinks are available.  A nice way of presenting information is that there
are areas devoted to specific groups (e.g., children, women, and teens) as well as various contexts (e.g., school, work and career).

www.ahcpr.gov/clinic/adhdsutr.htm
Title: Diagnosis of Attention-Deficit/Hyperactivity Disorder
Author: Agency for Health Care Policy and Research (AHCPR)
 This website is a technical review summarizing current scientific evidence related to ADHD as well as the value of various evaluation methods for the diagnosis of ADHD.  The sections of the website include Overview, Reporting the Evidence, Methodology, Findings, Future Research, and Availability of Full Report.  The author of this website is the Agency for Health Care Policy and Research (AHCPR).  AHCPR describes itself as “developing scientific information for other agencies and organizations on which to base clinical guidelines, performance measures, and other quality improvement tools, under the Agency's Evidence-based Practice Initiative, which was launched in the fall of 1996.”

www.adhd.com.au/ADHDaeti.html
Title: The etiology of ADHD: Evidence of a neurobiological basis and treatment implications
Author/Affiliation: Jacques Duff- Behavioral Neurotherapy Clinic
This website concludes that ADHD is caused by inherited factors that are manifest in abnormal brain morphology, and associated with an underlying neurological disregulation and underarousal of the frontal lobes.  Information provided at this site was helpful because an historical account for various explanations of ADHD were stated along with available empirical evidence to support their claims.  Sections in this website are divided as follows: Toxins, Family and environmental factors, Perinatal factors, Genetic evidence, Brain morphology, and Neurotransmitter activities.  A significant amount of information is provided on neurobiological treatment interventions.

www.btinternet.com/~black.ice/addnet/
Title: Collaborative Management of Students with ADHD
The department of education in conjunction with specialist medical practitioners provides information to support teachers and schools to effectively manage students with ADHD.  The information provided in this website are practical guidelines for teachers and school personnel to modify the educational environment and/or instructional approaches in order to enhance the opportunities for these students.  Topics which are covered include: problem solving, organization, sustained attention, social skills, impulsive/aggressive behavior, non-compliance, and off-task behaviors.

www.cdipage.com/adhd.htm
Title: About Attention Deficit Hyperactivity Disorder- ADHD/ADD
 This website provides information about attention deficit hyperactivity disorder, including diagnosis, treatment, classroom management, parent education, behavior modification, communication, and family relationships.  The information is updated as needed to reflect current research on ADHD.

www.eegspectrum.com/
Title: EEG Spectrum- Mental Fitness Training: Neurofeedback Research and Clinical Services
 This website provides extensive information about EEG training and its application to individuals diagnosed with ADHD.   Background information describing the training procedures, as well as its clinical application to a variety of conditions are outlined.  The authors imply that neurofeedback can be used for many conditions and disabilities in which the brain is not functioning normally.  Clinical neurofeedback services, clinical and scientific articles, professional training courses, as well as general news and announcements are covered under the primary topics.

www.findarticles.com
 This website can be used to search for research journal articles related to ADHD in addition to other topics.  An example of an article related to the assessment and diagnosis of ADHD that is available on the site is a study by Weiler (1999) published in the Journal of the American Academy of Pediatrics entitled “Mother and teacher reports of ADHD symptoms: DSM-IV questionnaire data.”  This article examines the component structure and distribution of scores of the Diagnostic Rating Scales, which are brief, DSM-IV-referenced parent and teacher questionnaires designed to screen children for ADHD symptoms.

www.gsi-add.com/default.asp
Title: ADD/ADHD Attention Deficit Hyperactivity Disorder (Dr. Gordon)
 Dr. Gordon along with GSI Publications, Inc. and Gordon Systems, Inc. has created this website to provide resources on information and products about ADHD.  Many of the materials are useful for clinicians and licensed professionals.  The web site provides a comprehensive list of assessment devices (i.e., rating scales, and structured interviews).  Furthermore, the research referenced is categorized as such: General, longitudinal, ADHD in adults, medication, and educational issues.  Likewise, there is an extensive list of books/videos (e.g., books in Spanish for parents and children).

www.health-center.com
 This website can be used to search for a variety of subtopics related to ADHD.  Subtopics are organized in folders according to their utility for kids, parents, physicians, teachers, teens, therapists, adults, etc.  The site also features the ADHD Living Guide Project, providing information on dealing with ADHD at school and home, funded by the Agency for Healthcare Quality and Research.  In addition, the website features a discussion bulletin board, a link to Medline, and page viewing in Spanish.

www.info@adhd.com.au
Title: Behavioural Neurotherapy Clinic
The authors of this website asserts that a particular treatment modality called neurotherapy appears to provide an effective treatment for ADHD, based on the studies reviewed. The authors discuss their study which will use sophisticated SSVEP (Steady State Visually Evoked Potential) Functional Brainmapping, IQ testing, neuropsychological assessment and behavioural measures before and after Neurotherapy to evaluate the effectiveness of specific Neurotherapy protocols as treatment for ADHD and Learning Difficulties. The study will be conducted over a period of twelve months, and will involve 60 ADHD children. Lastly, several large international clinical studies are
underway, some sponsors include EEGSPECTRUM, and the Biofeedback Foundation of Europe. The Brain Sciences Institute (Swinburne University) is also conducting a scientific investigation of the effectiveness of Neurotherapy. This innovative treatment approach and the related literature seem to be interesting and unique.

www.ldonline.org/ld_indepth/add_adhd/ael_success.html
Title: ADHD- Building Academic Success
Author: Appalachia Educational Laboratory (based on information provided by the Office of Educational Research and Improvement- OERI)
 The information provided in this website advocates a multimodal approach of treatment in the educational environment.  The authors adopt the idea that often times there is a mismatch between school environments and children with ADHD which may contribute to school failure.  In an attempt to address this problem, the following topics are discussed: ADHD and school failure, The mismatch of ADHD and school, School’s response to academic failure, School-Child Relationships: A transactional model, Multimodal treatment: Sharing responsibility for learning, Specific, individual accommodations, Comprehensive changes in school environments, and Monitoring performance.

www.newideas.net/attention_deficit/treatment_options/overview.htm
Title: The Attention Deficit Hyperactivity Disorder Information Library
Author: Dr. Douglas Cowan
 This Attention Deficit Hyperactivity Disorder Information Library is a part of the NewIdeas.Net family of ADD ADHD related websites. This website presents information in a straightforward manner suitable for parents. Treatment options, interventions, diagnostic information and other resources are discussed.  The website claims to glean its information from ADD/ADHD research findings as well as from the observations of professionals working in the field.

www.newideas.net/p0000392.htm
Title: ADHD- Diagnosing ADD & ADHD in Children and Teens (Dr. Doug Cowan)
 The information provided on this website is from a clinical perspective and appears to be written for parents.  The author states two main problems in the diagnosis of ADHD: 1) the over-diagnosis, which is a result of incomplete assessment procedures and 2) under-diagnosis, which he describes the school psychologists’ reports which include information appearing to describe many characteristics of ADHD, yet no formal diagnosis or label is prescribed to the child.  The author addresses several components in a thorough ADHD assessment: a) physical exam, b) in-depth parent interview, c) parent and teacher rating scales, d) clinical interview with the child, e) psychological testing, and f) TOVA.

www.nyspsych.org/cybercol/sept97/perry.html
Title:  Attention Deficit Hyperactivity Disorder (ADHD) Causes
Author:  Richard Perry, M.D.
This article reiterated the uncertainties with regards to the etiology of ADHD which points to the necessity for further investigations in this area.  According to the author, it is the general opinion from those in the field today that the causes of ADHD lie within the abnormalities of certain regions of the brain.  However, and as stated by the author in this case, conclusive evidence to support this aim has yet to be found.  On the other hand, evidence to demonstrate the genetic component to this disorder appears to be well established based on twin studies and studies of close family and close relatives of those with this disorder.  Finally, considerations must likewise be given to other factors such as pre- and perinatal complications and family situations.
 

VI.   CONCLUSIONS

     Etiology of ADHD remains unclear, although multiple factors such as genetic susceptibility, biochemical dysfunction, and environmental interactions have been proposed.  Accordingly, the various etiological models have different implications for diagnosis, treatment, and management.
     Extensive evidence exists which supports a heritability factor for  attention deficit hyperactivity disorder, with greater risk of the disorder being found among family members. Biological and neuroanatomical studies involving neuro-imaging have measured cerebral blood flow, cerebral glucose metabolism, and scanning techniques have documented physical abnormalities
in particular brain regions, especially the frontal lobes, for adults and children with ADHD. In addition, pregnancy and infancy complications can be an influencing factor.  Low birthweight children have been found to be particularly at risk for ADHD and other learning disorders. Current attempts focus more on a framework that incorporates a multiplicity of causal factors underlying ADHD.  The developmental perspective asserts the interactional nature of the organism with environmental contexts.
   Although the preponderance of evidence supports a genetic-neurobiological etiology, the developmental perspective has emphasized the interactional nature of the organism with environmental contexts.  Parental attributions, parental psychopathology, and behavioral management techniques have been found to be significantly related to the severity of expression of ADHD behaviors.  Neuropsychological testing has suggested that while the developmental trajectory for ADHD is linear, normal brain maturation processes may attenuate symptoms over time, although ADHD is generally believed to be a lifelong disorder.  Considering the heterogeneity of children diagnosed with ADHD, such diverse etiological evidence may facilitate an enhanced diagnostic structure with greater specificity.  That is, there may be distinct alternative pathways towards a diagnosis of ADHD.
 
 

Return to Top
 

I. ASSESSMENT

     The assessment of behavioral disorders, such as ADHD, must be guided by research on the classification and core features of the disorder.  Multiple sources and multiple varieties of information are necessary because the level of agreement among sources and between types of information is relatively low (Forbes, 1998). The current research strongly suggests that an optimal assessment protocol relies upon several methods, utilizing several different sources of information obtained from different settings and informants (Barkley & August, 1998).  ADHD diagnosis is increasingly common.  The driving force behind an ADHD diagnosis must not be to qualify a student to receive medical treatment to improve behavioral disruptions in the classroom or to receive extended time on standardized tests.  To circumvent these problems, direct and frequent communication between school personnel, medical professionals and family members needs to occur during assessment and treatment. Furthermore, assessment results should be used to design intervention strategies.
     The first diagnostic task in the classification of ADHD is ruling out alternative causes or establishing the primary problem (e.g., head injuries, metabolic or endocrine disorders, learning disabilities, substance abuse, and giftedness).  Secondly, the situational variations of problems directs that multiple sources of information be obtained from the different domains of the child’s life (e.g., home, school).  Thirdly, it is necessary to consider developmental issues (e.g., age of the child, maturity). Various assessment methods have been utilized to determine whether a child is displaying behaviors characteristic of ADHD at a developmentally inappropriate level and to a problematic or symptomatic degree.  These methods of assessment include: Interviews, standardized child behavior rating scales, peer-referenced assessment, laboratory measures, and direct observation. Multi-method

Interviews:

     The clinical interview is an essential component of the assessment process in diagnosing ADHD (Hechtman, 2000). Several interview schedules have been developed for use with children and adolescents as well as with primary caregivers.  Interviews may be conducted with a child’s teachers, parents and others such as school staff or childcare providers.
Teachers provide important observations of the child’s behavior, social skills, and academic performance.  It is especially helpful when teachers are able to identify which situations trigger problematic behaviors as well as what type of consequences result.  Furthermore, teacher reports about what instructional and intervention strategies that have been effective or ineffective is essential for both assessment and intervention planning (Brown, 2000).
     There are several advantages to a well-conducted, comprehensive interview such as building rapport and coverage of a broad range of topics related to ADHD diagnosis and treatment planning (Brown, 2000).  Hechtman (2000) outlines the important parameters that can be assessed in the clinical interview, which include: An extensive family history that explores family history of ADHD symptomatology as well as other psychiatric disorders, the family situation, parental stress level, and psychosocial adversity (family conflict, social support, poverty, etc.). Other relevant subjects to cover in the interview are details of the referral concerns; medical and developmental history; and academic performance and experience; behavior problems and peer relationships. Furthermore, diagnostic interviews are typically tied to the most recent revisions of the DSM.
     Some disadvantages may be that they are time consuming, and may not provide norm-referenced information.  In addition, the reliability of child self-report interviews (before age 9) may be questionable. Children, particularly over age 10, tend to be reliable in reporting internalizing symptoms such as depression, whereas they tend to underreport externalizing symptoms such as aggression.  Although parental reports of their children’s behavior are generally reliable, excessive stress may result in increased reports of behavior problems (Brown, 2000).   A list of the more common interview schedules in provided as well as recent studies researching the use of such instruments. Popular instruments include the Diagnostic Interview Schedule for Children (DISC-R; Schwab-Stone, Fisher, Piacetini, Shaffer, Davies, and Briggs, 1993), the SCICA (Structured Interview for Children and Adolescents (SCICA; McConaughy & Achenbach, 1994), the Diagnostic Interview of Children and Adolescents (DICA-R; Boyle, Offord, Racine, and Szatmari, 1996), and the Structured Developmental History (SDH) of the multidimensional Behavior Assessment System for Children (BASC) (Kamphaus, Reynolds, & Hatcher, 1999).
     The use of structured interviews adds a standardized, quantifiable dimension to the clinical assessment (Hechtman, 2000).  Brown (2000) recommends the use of two widely used structured interviews, the Diagnostic Interview Schedule for Children (DISC) and the Semistructured Clinical Interview for Children and Adolescents (SCICA) due to their specific diagnostic criteria and relatively high reliabilities.
     Schwab-Stone, Fisher, Piacetini, Shaffer, Davies, and Briggs (1993) examined the test-retest reliability and internal consistency of the Diagnostic Interview Schedule for Children (DISC-R).  Forty-one adolescents and thirty-nine of their parents were administered the DISC-R.  Test-retest reliability for symptom scales was excellent for the parent DISC-R and good for the child version, except for Oppositional Defiant Disorder.  Internal consistency was satisfactory for symptom items comprising most diagnoses.
     McConaughy and Achenbach (1996) tested the predictive power of the Semistructured Clinical Interview for Children and Adolescents (SCICA), combined with a standardized parent scale, the Child Behavior Checklist (CBCL), and a standardized  teacher scale, the Teacher's Report Form (TRF), for children with emotional and behavioral disorders (EBDs) or learning disabilities (LDs) and nonreferred children. The authors found that the majority of SCICA, CBCL, and TRF scales were able to significantly discriminate between subjects with EBDs and nonreferred subjects. Several scales were also able to discriminate between subjects with EBDs and LDs.
      Another structured interview that is commonly utilized for ADHD assessment is the Diagnostic Interview for Children and Adolescents (DICA-R). Boyle, Offord, Racine, and Szatmari (1996) compared the reliability and validity of the DICA-R and theOntario Child Health Study Scales, (OCHS-R), a self-administered checklist, on two administration occasions, 1-3 weeks apart.  Differences in test-retest reliability between the two instruments were small.  Validity coefficients were slightly better for the checklist classifications of disorders listed in the DSM-III-R.  Differences in reliability and validity were also small between the two measures.
     A structured diagnostic clinical interview with the child’s primary caregiver is also useful (Ammerman, Hersen, & Last, 1999).  One instrument that can be used or this purpose is the Structured Developmental History (SDH).  The SDH is one component of the multidimensional Behavior Assessment System for Children (BASC).  The SDH is an extensive history and background survey that may be used as either part of an interview with the child’s primary caretaker administered by the clinician.  This comprehensive questionnaire systematically gathers diagnostic information including developmental events, medical problems, social history, and family problems that may affect the child’s behavior (Kamphaus, Reynolds, & Hatcher, 1999).

Behavior Rating Scales:

     Behavior rating scales (teacher or parent) have become more commonplace in child assessment of ADHD and are designed to gather information about ADHD symptoms, general social competence, comorbid disorders, and situational variability in behaviors.  These instruments are practical and cost-efficient, although they have been criticized for their limited interpretive value.  The Behavior Assessment System for Children (BASC- Parent & Teacher forms-PRF & TRF; Reynolds & Kamphaus, 1992) and the Achenbach Child Behavior Checklist (CBCL- Parent & Teacher scales- PRS & TRS; Achenbach & Edelbrock, 1983) appear to be the most widely used and have the most support for reliability and validity.  Other available behavior rating scales include: Connors’ (CTRS 39, 28 and CPRS-R; Connors, 1989); the ADHD Symptoms Rating Scale (ADHD-SRS; Holland, Gimpel, and Merrell, 1998); the Devereux Scales of Mental Disorders (DSMD; Smith, Wigenfeld, Hilsenroth, Reddy, and LeBuffe, 2000); Attention Deficit Disorder Evaluation Scale (ADDES; McCarney, 1989); ADD-H Comprehensive Teacher Rating Scale (ACTeRS; Ullmann, Sleator, and Sprague, 1991); and the AD/HD Rating Scale-IV (Teacher and Parent forms; DuPaul, Anastopoulos, Power, Murphy, and Barkley, 1996).  Following are research studies regarding the use of various scales.
Kamphaus, Reynolds, and Hatcher (1999) review recent research on the use of BASC and found that most of the studies focused on the assessment and diagnosis of clinical populations such as ADHD.  The confluence of finding suggests that the BASC is comparable to the CBCL for the diagnosis of ADHD Combined Type.   However, the BASC appears to be superior to the CBCL for diagnosing children with externalizing disorders, specifically ADHD Primarily Inattentive Type. Researchers identify the rational derivation of the BASC scales as another advantage of the BASC over the CBCL.
     Vaughn, Riccio, Hynd, and Hall (1997) compared the effectiveness of discriminating ADHD subtypes using the Parent Rating Scale and the Teacher Rating Scale of the Behavior Assessment System for Children (BASC) and the Parent Report Form and the Teacher Report Form of the Achenbach Child Behavior Checklist (CBCL).  Their results indicated that correlations were significant for a number of scales.  Discriminant analysis did not strongly favor either measure in differentiating children with ADHD from those who did not meet diagnostic criteria.  The authors stated that results show the BASC Teacher Rating Scale has better predictive ability for children who do not meet ADHD criteria.  For subtypes of ADHD, specifically the predominantly inattentive type, results show an advantage for the use of the BASC.
     Connors, Sitareios, Parker, and Epstein (1998) evaluated the factor structure, reliability, and criterion validity of the revised Connors Parent Rating Scale (CPRS-R).  Exploratory and confirmatory factor-analytic results revealed a seven-factor model including the following factors: Cognitive Problems, Oppositional, Hyperactivity-Impulsivity, Anxious-Shy, Perfectionism, Social Problems, and Psychosomatic.  The psychometric properties of the revised scale seem to demonstrate good internal reliability
coefficients, high test-retest reliability, and effective discriminatory power.  Advantages of the CPRS-R include a corresponding factor structure with the Connors Teacher Rating Scale-Revised and comprehensive symptom coverage for ADHD and related disorders.
     Holland, Gimpel, and Merrell (1998) investigated the reliability and validity of the ADHD Symptoms Rating Scale (ADHD-SRS) used by 1006 participants.  The results indicate that the ADHD-SRS possesses strong internal consistency reliability and test-retest reliability and moderate cross-informant reliability.  In addition, this instrument was shown to have strong content validity.  The authors state several advantages of the use of this instrument over many currently existing rating scales.  One advantage is that the items are based on the DSM-IV classification of ADHD and its symptomatology.  In addition, with 56 items designed to purely assess for ADHD characteristics, this instrument generates a more thorough and complete assessment.
 Smith, Wigenfeld, Hilsenroth, Reddy, and LeBuffe (2000) evaluated the validity of the Devereux Scales of Mental Disorders to discriminate between children and adolescents with ADHD, Conduct Disorder (CD), and no clinical diagnosis.  The results of the study did support the use of the DSMD for distinguishing between clinical and nonclinical subjects.  However, the DSMD Total, Composite and Scale score did not differentiate between the ADHD and the CD youths.  Although the DSMD appears to perform as well or better than other behavior rating scales at differentiating clinical from nonclinical groups, the DSMD is not as able to make subtle distinctions between disorders.  However, the participants with ADHD scored higher on the number of ADHD-related items endorsed and the participants with CD scored higher on the number of CD-related items endorsed.  Thus, clinicians using the DSMD may be able to differentiate between these two highly related disorders by examining the number of disorder-specific items endorsed.

Peers:

     Ammerman, Hersenand, and  Last (1999) suggest that “when social problems are a primary concern, peer measures such as positive and negative nomination procedures, peer rating scales, and/or peer reputation measures are useful in providing important information about the extent and types of peer problems” (p. 67).  Schaughency and Rothlind (1991) also suggest the use of peer nominations in assessments of ADHD.  Specific items such as “can’t pay attention, can’t wait turn, and can’t sit still” correlated well with teacher and observer measures of inattention and hyperactivity.
     Cornett-Ruiz and Hendricks (1993) investigated the effects of labeling and ADHD behaviors on peer judgments.  Fourth through sixth grade subjects watched a brief video of a child displaying stereotypical ADHD behaviors or normal behaviors and was labeled as either ADHD or normal.  Then, the peer raters completed first-impressions rating scales, made predictions regarding subsequent success, and evaluated a hand-written essay.  Findings revealed that the ADHD behavior but not the label resulted in a significant negative impact on the peer raters’ first-impressions and prediction scales.
     Although peer ratings may make a valuable contribution to diagnostic assessment, the evaluation team should consider the effect that a sociometric instrument may have on the child.  For example, the peer rankings may result in increased anxiety or may encourage teasing.

Behavioral Observations:

     Behavioral observations provide opportunities to compare the child’s behavior in a variety of settings in order to gain a more holistic view of the child and a more objective sense of his or her functioning. However, conducting observations can be expensive and time consuming, and are limited in the ability to observe an adequate sample of behavior. Examples of behavioral observation instruments include the Behavioral Assessment System for Children-Monitor for ADHD (BASC- Student Observation System SOS; Reynolds and Kamphaus, 1992) and the Child Behavior Checklist (CBCL- Direct Observation Form DOF; Reed & Edelbrock, 1983 ).
     Assessors can also maximize time spent conducting assessment by incorporating observations during testing into the evaluation report.  Glutting, Robins, and De Lancey (1997) compared the test session behaviors of children with ADHD to unclassified children from the GATSB standardization samples. The ADHD children were matched to the control children according to the background characteristics of age, race, gender, parent educational attainment, and overall cognitive ability.  Test-taking behaviors were rated according to the Guide to the Assessment of Test Session Behavior (GATSB) for the Weschler Intelligence Scale for Children-Third Edition (WISC-III) and the Weschler Individual Achievement Test (WIAT) following the administration of the WISC-III. Results indicated that ADHD children could be distinguished from the matched GATSB control children on the test behavior variables of Inattentiveness, Avoidance and Uncooperative Mood. The inattentiveness dimension of the GATSB best differentiated between the two groups.
     Valid ADHD diagnosis is complicated by heavy reliance upon parent and teacher reports as well as children’s performance on tasks which may be confounded by comorbid learning difficulties. In lieu of a standard assessment technique, Costantino, Colon-Malgady, Malgady, and Perez (1991) “applied an old technique to a new problem by examining attention to projective stimuli.” A structured thematic apperception technique, the Tell-ME-A-Story (TEMAS), was utilized to measure attention to pictorial stimuli depicting characters, events, settings, covert psychological conflicts.  The TEMAS was administered to Black, White and Hispanic ADHD and non-ADHD school-age children.  The results revealed that the ADHD children were significantly more likely that than the non-ADHD children to omit information in the stimuli about characters, events, settings, and psychological conflicts.  Furthermore, prompting with structured inquiries by test examiners was three times more likely to be required for the ADHD children than the non-ADHD children.
     Handen, McAuliffe, Janosky, and Feldman (1998) observed children in a laboratory playroom setting to determine whether children identified as ADHD or controls differed on activity and attentional measures.  Children with ADHD were further divided into ADHD + conduct problems (ADHD + CD) and ADHD-only subgroups.  Results indicated that the ADHD-combined group was significantly more vocal and engaged in a significantly greater number of toy changes than controls during independent play.  Significant group differences were also noted during the restricted academic task, with the ADHD-combined and ADHD + CD groups more off-task and engaging in a greater number of toy touches than controls.

Laboratory Measures:

     Laboratory measures have been used to obtain direct core features of ADHD (e.g., attention span, impulsivity, and motor activity).  While other assessment measures may be criticized for their validity (e.g. unclear comparison standards of children of the same age, cultural variations) and/or subjectivity (e.g., child ratings versus parent ratings), laboratory measures are able to account for these inconsistencies by the objective nature of the assessment.  However, some limitations may involve standardization issues, normative data, and generalization to other contexts.  Specifically, a computerized assessment of attention and impulsively may not relate to assessments of a child’s adaptive behavior in broader social contexts such as home, school, and peer groups.  Thus, greater research is needed in this area to determine its generalization utility.
 The Continuous Performance Test (CPT) is probably the most widely used instrument for attention span or vigilance.  There have been several variations on the basic method of the original CPT, but most researchers continue to follow the design of presenting a series of random letters and requiring the participant to respond when a specific letter, usually an X, appears or when a specific letter, usually an A, is followed by another specific letter, usually an X.  Failure to respond to the specified letter or letter sequence is usually interpreted as a result of inattention.  Responses to incorrect letters or letter sequences are usually interpreted as impulsivity (Forbes, 1998).
     Widely used laboratory measures for ADHD are: The Continuous Performance Test (CPT; Rosvold, Mirsky, Sarason, Bransome, and Beck, 1956), Connors’ Continuous Performance Test (CPT; Connors, 1995), Matching Familiar Figures Test (MFFT; Kagan, 1964), and Test of Variables of Attention (TOVA; Greenberg, 1991).
     Corkum and Siegel (1993) reviewed research studies that employed the CPT in order to examine the possibility of sustained attention deficits in children with ADHD.  The authors concluded that there is no compelling evidence for a sustained deficit in ADHD children.  An alternative theoretical model for understanding the results of CPT performance in ADHD is also provided.
     Mirsky, Pascualvaca, Duncan, and French (1999) present a neuropsychological model of attention based on a factor analysis of data derived from more than 600 children and adults.  The model divides attention into different elements or factors including the capacities of encoding, focusing, executing responses, sustaining attention, shifting attention, and a measure of response stability.  A description is also given of an on-going investigation of children referred to an inner-city family clinic for evaluation of ADHD.  The findings of this ADHD study indicate that several aspects of attention are impaired in children with ADHD and that these impairments are probably not attributable to learning disorders.
     The authors also present an Attention Battery, modified for children, derived from neuropsychological tests in order to assess the various elements of attention.  Preliminary findings from the current study suggest that ADHD children are impaired in various elements of attention as compared to control children: The capacity to focus on a task when distracted and to execute brisk, efficient responses (The Trail Making B Test and the Stroop Word Test); the ability to shift attention in a flexible, efficient manner (the Wisconsin Card Sorting Test); and the ability to sustain attention in both the visual and auditory modalities (CPT); and the capacity to maintain a stable response rhythm in the auditory modality (CPT).  In addition, the preliminary results suggest that ADHD children tended to have more rapid responses than control subjects, yet the responses tend to be more impulsive and more poorly regulated.  For instance, the ADHD children had more CPT commission errors as well as increased Reaction Time (RT) Variance on the auditory CPT in comparison to control children.
     In order to address the question of the possible contributions of learning disabilities to documented attention deficits, the authors also compared the assessment results between the subgroup of children diagnosed with ADHD alone (ADHD) with the subgroup of children diagnosed with ADHD and a learning disability (ADHD+LD).  The only significant difference found between the groups was on the Word and Color naming subtests of the Stroop Test, which appears to be consistent with generally poor reading abilities. Thus, the authors conclude that the impaired attentional elements in the ADHD population are not generally attributable to learning disabilities.
     McGee, Clark, and Symons (2000) found that children with Reading Disorders (RD) had higher scores than both ADHD children and control children on the Connors’ CPT.  Furthermore, the ADHD children did not have significantly higher CPT overall index scores than the control children did.  Phonological awareness tests, consisting of two auditory and two visual  subtests from the Woodcock-Johnson Psychoeducational Battery--Revised,  distinguished the RD children from both the ADHD and the control children. This finding may be due to the Connors’ CPT requiring rapid identification of letters, which is basic deficit in RD children.  The authors point out the danger that RD children could be falsely diagnosed with ADHD if the Connors’ CPT overall index is used as diagnostic tool. ADHD children who did fail the Connors’ were rated as more hyperactive by their teachers. The Connors’ CPT did demonstrate several strengths in this study.  There were no age, order or fatigue effects.  CPT performance was uninfluenced by visual-motor integration, fine motor speed, visual processing speed--with the exception of reaction time--or SES.  In agreement with other studies, the authors found that CPT scores do not consistently identify attention in ADHD children.  In conclusion, the utility of the Connors CPT for differential diagnosis of ADHD is questioned.
     Some clinicians believe that the CPT measures psychomotor speed function rather than sustained attention.  In order to examine this relationship, Chae (1999)  conducted a correlation study between the Performance IQ (PIQ) of the WISC-III and the TOVA, which is commonly used as a CPT.  The relationships between the Freedom from Distractibility (FD) and Processing Speed (PS) indexes of the WISC-III, which are often included in ADHD assessment, with the TOVA were also examined.  The results of forty ADHD children studied indicate that there was no correlation between the TOVA and the PIQ of WISC-III.  Furthermore, the insignificant correlation between the WISC-III Symbol Search subtest, which is regarded as simply measuring psychomotor speed, and Response Time of TOVA supports the conclusion that the TOVA is not a simple of psychomotor speed for the evaluation of ADHD.  It appears that the PIQ and the TOVA measure different qualities of psychomotor functioning.  In addition, the significantly negative correlation between the Object Assembly (OA) and Picture Arrangement (PA) subtests with the TOVA Inattention indicates that ADHD children will not do well in the tasks that require sustained attention.  Hence, the OA and PA WISC-III subtests may be useful screening tools for ADHD.
     Forbes (1998) conducted clinical tests of the TOVA to distinguish between referred children with ADHD/ADD and “other” clinical diagnoses.  The ADHD group differed from the “other” group on TOVA variables and most measures from the Revised Connors Teachers Rating Scale (RCTRS) and ADD-H Comprehensive Teacher’s Rating Scale (ACTeRS).  These results indicate these instruments are measuring relevant but different dimensions of attention deficit disorders.  The TOVA classification criterion of any one variable correctly identified 80 percent of the ADDHD/ADD group and 72 percent of the “other” group. In addition, cases misclassified by teacher ratings were often correctly classified using TOVA.  The authors note that, because the rating scales and the TOVA have inherent differences (e.g., differences in populations studied, differences in diagnostic criteria, differences in scoring), making meaningful comparisons is difficult.  Thus, both appear to be contributing significant amounts of unique information to an ADHD assessment.
     A recent study assessed the usefulness of the CPT, the MFFT, and the actigraph (an acceleration-sensitive device with a solid-state memory used to count and store the number of times accelerations change above a certain threshold per unit time) used in combination to differentiate boys with ADHD from control subjects and to classify them into subtypes (Inoue, Nadaoka, Oiji, Morioka, Totsuka, Kanbayashi, and Hukui, 1998).  In this study, the actigraph measured motor activity in the subject’s trunk area.   Regarding the MFFT, the authors suggest that the “fast inaccurate” category is an important diagnostic sign in ADHD as 16 out of the 20 participants with ADHD were classified in this category.   The participants with ADHD and the controls were differentiated with enough high sensitivity and specificity by the actigraph and the CPT.
    Marks, Himelstein, Newcorn, and Halperin (1999) identified ADHD subtypes using actigraphs and CPTs with a clinically referred sample of participants ranging in ages from 7-11 years old.  Results indicate that the hyperactive-inattentive group was impaired on measures of intellectual functioning and academic achievement relative to the other 3 groups.  In addition, the impulsive-inattentive group was generally rated as more aggressive, although this difference was not statistically significant for all measures.  The authors conclude that these results suggest that such laboratory-based measures may be an effective strategy to categorize diagnostic subgroups of ADHD.
     Silberstein, Farrow, Levy, Pipingas, Hay, and Jarman (1998) used a novel brain electrical imaging method to investigate rapid and continuous changes in brain activity during the CPT in 17 boys (ages 1-14 years) with ADHD and 17 matched-aged controls.  In the interval between the appearances of the A and the X of the correct trials of the CPT-AX, control boys showed transient reductions in steady-state visually evoked potential (SSVEP) latency at right prefrontal sites.  By contrast, boys with ADHD showed no changed or an increase in prefrontal SSVEP latency at right prefrontal sites.  The use of these laboratory measures in this study provide evidence for neurological differences in children with ADHD.  Specifically, these results suggest an increased speed of prefrontal neural processing in children without ADHD following a priming stimulus, and a deficit in such processes in children with ADHD.
 

II. DEVELOPMENTAL PERSPECTIVE

     Utilizing a developmental framework is a useful practice in the assessment of ADHD. ADHD can be viewed as a developmentally relative disorder as findings indicate that ADHD symptoms decline significantly in prevalence and/or change in expression with age across childhood and adolescence.  Furthermore, what we presume to be subtypes of ADHD (ADHD-HI and ADHD-C) may be viewed instead as two different developmental stages of the same disorder (Barkley, 1998).
     As ADHD children tend to progress at a relatively constant rate but with delays in both social development and cognitive tasks when compared to their non-ADHD peers, Mirsky, Pascualvaca, Duncan, and French (1999) speculate whether ADHD represents a developmental delay.  The authors point out that the hypothesis that this “developmental lag” does not necessarily mean that ADHD children will eventually catch-up with their peers is supported in the research literature.  In fact, follow-up studies indicate that approximately 70 to 80 percent of children diagnosed with ADHD continue to present symptoms of inattention and impulsivity into adolescence and early adulthood.  As it is likely that the developmental course and outcome of ADHD children depend on the specific nature of their attention deficits, the authors underscore the importance of assessing specific elements of attention (see Laboratory Measures). Although it is clear that “the diagnosis of ADHD is given to a group of children who show marked variability in their clinical presentation and response to treatment”, little is known about the possible differences in developmental trajectories and outcomes between ADHD subgroups.
    When assessing for ADHD, one must gather historical, behavioral, and socio-emotional information about an individual from multiple sources, informants and contexts.  Furthermore, as indicated in the DSM-IV-TR, it is critical that the evaluation team considers whether the child’s behaviors are developmentally inappropriate and that there is clear evidence of significant impairment in social and/or academic functioning.  Thus, reflected in the assessment process is a regard for the importance of the interactional nature of biological, environmental and developmental constituents.  Current objectives for refining assessment methods should emphasize the importance of developmentally sensitive measures.  At this time, behavior rating scales and some structured interview schedules seem to incorporate this aspect best because of their extensive normative base.
     Using CPTs and actigraphs, Inoue, Nadaoka, Oiji, Morioka, Totsuka, Kanbayashi, and Hukui (1998) considered the developmental perspective in the analysis of their findings.  Results suggest that younger elementary schoolchildren are more hyperactive, inattentive, and impulsive.  Therefore, the authors suggest that ADHD should be diagnosed taking into consideration the age of the child.
     Age and sex relationships were examined with measured performance in the CPT in a study by Lin, Hsiao, and Chen (1999).  The participants were 341 randomly selected school children between the ages of 6 and 15.  Results revealed that the hit rate, false alarm rate, and sensitivity of the CPT measures were associated with age.  These findings underscore that failing to take variables such as age and gender into consideration may result in misdiagnosis or misinterpretation of assessment results.
     Fisher, Barkley, Edelbrock, and Smallish (1990) studied various outcomes in adolescence of children diagnosed as hyperactive.  One hundred hyperactive children (aged 12-14 years) were tested on measures of academic skills, attention and impulse control, and select frontal lobe functions and, then, were tested in follow-up eight years later.  Follow-up results indicated that hyperactive subjects demonstrated impaired academic achievement, impaired attention and impulse control, and greater off-task, restless, and vocal behavior, compared with control subjects.  Thus, it was concluded that hyperactive children may remain chronically impaired in academic achievement, attention, and behavioral disinhibition well into their late adolescent years.
     Barkley (1997) addresses several problems in diagnosing ADHD across the lifespan using the DSM-IV items.  First he states that much of the content of the inattention items actually refers to the persistence of goal-directed responding and resistance to distraction (interference control).  He argues that the term inattention, is in many ways misleading, as distraction and impersistence have nothing to do with perception of information processing, which is usually associated with
attention.  A second argument is that the items reflecting poor behavioral inhibition are underrepresented relative to their importance in identifying the disorder.  Barkley notes that even though the symptoms of inattention become useful discriminators of ADHD in school-age children, they may become increasingly less useful by adulthood.  Thus, only the more serious cases of ADHD would be more likely to be detected by these inattention items, and, even then, not particularly well (Barkley, 1997).
     Barkley offers suggestions to address the problem of the developmental insensitivity of these assessment instruments, by doing what has already been done in the diagnosis of mental retardation or learning disabilities such as reading disorders.  Specifically, he proposes that a wide range of items must be used that represent the broad developmental span for the cognitive impairment of interest.  In addition, a flexible cutoff score must be chosen that is developmentally referenced in order to continue to reflect the same degree of deviance at all ages (Barkley, 1997).
     The developmental perspective is an essential piece in the assessment of ADHD as many of the symptoms tend to be subjective measures (i.e. difficulty sustaining attention, easily distracted, etc.) as evidenced by inconsistency between informants.  Furthermore, the history of its classification in the different versions of the DSM illustrates the inconsistencies and confusion in the agreement of ADHD.  In addition, failing to incorporate one’s developmental level in the assessment procedures may lead to misdiagnosis as measured by the DSM.
 

III. OPTIMAL ASSESSMENT BATTERY

     To date, ADHD, like any other mental disorder, cannot be firmly diagnosed by one medical or objective procedure (August, 1998).  The best approach for evaluating individuals for ADHD is a comprehensive, multi-method, multi-informant behavioral assessment that addresses the specific referral questions.  As a best-estimate approach, the following assessment strategies, also mentioned above, should be used in a standard ADHD assessment: Diagnostic interview, behavioral rating scale, behavioral observations, and laboratory measures that examine different elements of attention.  In addition, a peer sociometric measure may be of use if the child is having social difficulties.  Research has shown that many of the available methods do not correlate highly with one another, which lends support to the rationale for incorporating more than one method.
     The assessment practice of ADHD has included the use of diagnostic interviews, behavioral rating scales, peer-referenced measures, behavioral observations, and laboratory measures.  An undergirding theme in assessing for ADHD is the developmental perspective, which is a reflection of the developmental underpinnings associated with this disorder.  At the present time, it is recommended that measures that have a solid normative base such as that found in most behavioral rating scales and/or diagnostic interviews remain a necessary component of the broad assessment.  Currently, the most effective method for ADHD assessment is conducting a comprehensive behavioral assessment that utilizes multiple methods and informants.  While assessments may be conducted by school personnel and/or medical professionals in the school environment or clinical settings, it is imperative that these professionals and informants communicate and work together as an evaluation team to discuss the students’ situation. Furthermore, the evaluation team should discuss the confluence of assessment results as well as the developmental level of the child when attempting to interpret findings and make a diagnosis.  Failure to establish effective communication may result in misdiagnosis.
 
 

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I. TREATMENT

 A variety of interventions have attempted to ameliorate the cognitive, behavioral, academic and social disturbances, which accompany ADHD.  Among the most popular treatments are pharmacological, behavioral, cognitive-behavioral and multi-modal strategies.  All treatments have demonstrated some promise, but a single effective treatment has not been identified.  The heterogeneity of symptoms and frequent co-occurrence with other behavioral and psychological conditions contribute to the difficulty in treating ADHD.  Few studies have examined the efficacy of treatments across developmental stages.  Despite the evidence that various symptoms of the disorder seem to improve somewhat with age, psychologists know little about which treatments address the salient features of this disorder across different stages of the life span.  Listed below are examples of research literature, which examine the effectiveness and/or ineffectiveness of various treatment approaches that have been utilized for ADHD.

Studies of Pharmacotherapy for ADHD:

     Psychostimulants are one of the most common treatments for ADHD in children and include methylphenidate (MPH, also commonly known as Ritalin), clonidine, dextroamphetamine, and Adderall among the most commonly prescribed in the United States (Manos, Short, & Findling, 1999).  While several studies have demonstrated their effectiveness, the use of psychostimulants with children continues to be controversial.
     Little information exists concerning the long-term effects of psychostimulants, however, there is no conclusive evidence that careful therapeutic use is harmful (National Institute of Health, 1998).  Because the behavioral and side effects of stimulants can vary significantly across dosages and individuals, the importance of evaluating the medication response should be stressed (Roberts & DuPaul, 2000).  Evaluations should include repeated assessment of child behavior across dosages including placebo and/or non-medication conditions (as a basis of comparison) in order to ensure that the child is not receiving inappropriate dosages.
Despite its controversy, this type of treatment has been used in children as young as two years old.  Research has shown that clinical improvement in behavior occurs in as many as 75-92 percent of those with the hyperactive-impulsive form of ADHD and results in normalization of behavior in approximately 50-60 percent of these cases on average (Barkley, 1997).
      Studies have estimated that 3 percent of US schoolchildren take medication for ADHD, while as many as 7 percent of US children may have the disorder (Lang, 1997).  Recently, public concerns have been raised about the dramatic rise in ADHD diagnosis and stimulant prescription.  Jensen et al. (1999) investigated the rates of ADHD diagnosis and treatment in four U.S. communities (Atlanta, Georgia; New Haven, Connecticut; Westchester, New York; and San Juan, Puerto Rico).  The epidemiological procedures used for the study entailed two lay interviewers separately interviewing children (ages 9-17) and their primary caretakers in their homes using a computer-assisted version of the National Institute of Mental Health Diagnostic Interview Schedule for Children (NIMH-DISC-2.3). Only the children for whom the DISC data permitted an ADHD diagnosis were included in the analyses.  The researchers found a low overall prescription rate, only 12% of children with ADHD received stimulant treatment.  There were no significant differences in prescription rates between the four sites.  Although half of the children who were taking stimulants did not meet full diagnostic criteria for ADHD, this may have been a function of a positive response to stimulant treatment.  However, these children had high levels of ADHD symptoms.  The authors conclude that concerns about overprescription were not supported by the study data.  Furthermore, more ADHD children received school-based or psychotherapeutic services (one-fourth to one-third) than medication (one-eighth).  The authors underscore the lack of services provided to ADHD children, with these findings paralleling previous reports that only about one-third of children in need of mental health services actually receive care.
     LeFever, Dawson, and Morrow (1999) attempted to determine the extent of medication use for ADHD among children enrolled in public schools in two different cities in Virginia.  The study population included all students enrolled in grades 2 through 5 in city A (n=5767), and city B (n=23967).  Results indicated that 8-10 percent of the students received medication for ADHD.  The majority (90 percent) of children receiving medication were prescribed MPH, and 5 percent received MPH in combination with other drugs.  The percentage of students receiving ADHD medication generally increased with grade; the increase from second to fifth grade was from 7-9 percent and 7-10 percent in cities A and B respectively.  The percentage was highest in fifth grade, in which 18 percent and 20 percent received medication in cities A and B, respectively.  The study also included sex and race differences: 17 percent of Caucasian males, 9 percent of African-American males, 7 percent of Caucasian females, and 3 percent of African-American females received ADHD medication (these findings were consistent between the two districts).  The difference between the findings of this study and the previous study indicate that both overprescription and underprescription occur and are likely to be region-, community-, and provider-specific (Jensen et al, 1999).
      While the the LeFever, Dawson, and Morrow (1999) study included school-aged children, psychotropic medical use has also been studied in younger children.  Rappley, Mullan, Alvarez, Eneli, Wang, and Gardiner (1999) investigated the diagnosis and treatment methods used in very young children with ADHD.  Their study included 223 children aged 3 years or younger who had a clinical diagnosis of ADHD.  In addition, many had conditions commonly comorbid with ADHD (44 percent), other chronic health conditions (41 percent), and injuries (40 percent).  More than half of the children received psychotropic medication (57 percent) while 26 percent received psychological services.  Among those receiving psychotropic medications, 54 percent received one medication and 45 percent received a combination of medications.  Twenty-two different medications were used by children included in this sample, with MPH and clonidine hydrochloride among the most frequently used.  The authors do point out that, “the use of psychotropic medications as described for these children is not approved by the FDA” (Rappley, et.al., 1999).
 The research described previously highlights the prevalence of psychotropic medical use in children with ADHD.  We will now turn to studies that highlight different effects of such medications.
     One commonly reported side effect of psychostimulant use is sleeping difficulties.  Stein (1999) compared the parental perceptions of sleep problems in stimulant treated children with ADHD, untreated children with ADHD, and a control group children receiving routine pediatric care.  Thirty percent of the stimulant treated children with ADHD versus 10 percent of the untreated children with ADHD reported delayed sleep onset or insomnia every night.  The stimulant treated children with ADHD were three times more likely to report severe sleeping problems than the untreated children with ADHD.  The authors point out that the findings of this study concur with previous studies indicating that children with ADHD who take stimulant medications are at increased risk for insomnia as well as other sleeping difficulties.
     Schachar, Tannock, Cunningham, and Corkum (1997) studied the long-term effects of MPH in children’s behavior as well as the medication side effects as reported by teachers and parents.  The study duration was scheduled for 12 months, with this interim report covering the first four months of treatment.  The findings include differences in adherence to treatment, with more families and children in the placebo group discontinuing treatment due to ineffectiveness.  Medication side effects were the primary reason for discontinuing use in the medication group.  Teacher ratings revealed greater behavioral improvement for the MPH group.  In contrast, parents reported no difference between the groups (both groups improved overall).
     Another study included observations of student’s behavior and academic performance in response to the effectiveness of Adderall with ADHD children.  Swanson, Wigal, Greenhill, Browne, Waslik, Lerner, Williams, Flynn, Agler, Crowley, Finberg, Baren and Cantwell (1998) included 30 children in their study to compare the effectiveness of 5, 10, 15, and 20 mg of Adderall to the best dose of Ritalin.  Results indicated that all doses of the two medications were superior to the placebo.  However, higher doses of Adderall lasted longer than lower doses of Adderall and Ritalin, and these effects were apparent in the children’s behavior and academic performance.  This longer lasting effect is of particular interest because it has been reported that higher doses of Ritalin give a more powerful effect instead of a longer lasting effect.
     Another study was conducted comparing the effectiveness of MPH and Adderall in children ranging in age from 5 to 17 years.  More specifically, the study was designed to compare the effectiveness of Adderall given once in the morning and that of MPH given in the morning and at noon.  All forty-two participants met the DSM-IV criteria for ADHD and were assigned to one of three groups (Adderall, MPH and control).  Teacher reports, parent ratings as well as standardized measures of the side effects were included in the measurement procedures.  Results indicated that both MPH and Adderall are effective treatments as measured by the teacher and parent ratings of behavior.  In addition, a single-dose treatment of Adderall was shown to be as effective as two daily doses of MPH.  These results may increase the possibility of managing treatment without having to involve the school in medication administration.
     As the majority of stimulant response studies have been conducted on children, there is a paucity of studies examining stimulant efficacy for adolescents with ADH.  Barkley, Connor, and Kwasnik (2000) evaluated the utility of employing systematic assessment of stimulant response with adolescents (ages 12-17) with ADHD in a routine outpatient clinical setting.  Thirty-five teenagers with ADHD rotated through five blind drug conditions: Two daily doses of Adderall (5 mg and 10mg), MPH (5mg and 10mg), and a lactose placebo.  Results revealed no significant effects of the medication on parent or teacher ratings between groups.  The authors note confounding variables such as the teachers completing less than half of the weekly ratings across the five weeks of the study. Subjects taking 10mg of Adderall made significant improvements on an inhibition control task (Stroop Color Word Association Test) but not on an attention task (CPT).  Teens reported less severe side effects for the 10mg dose of Adderall than the 5mg dose of MPH.  Non-blinded global clinical judgements of stimulant response, based upon multiple sources of information, suggested that both Adderall (46%) and MPH (40%) appear to be clinically effective in the treatment of adolescents with ADHD.  However, 14% did not respond to either stimulant.  The authors discuss several logistical problems with conducting this type of study using rating scales in typical outpatient practice and offer recommendations (e.g., a daily report card presented to each teacher by the teenager) for future studies.
     Frankel, Cantwell, Myatt, and Feinberg (1999) used the Achenbach Child Behavior Checklist (CBCL), the Social Skills Rating System (SSRS), and the Piers-Harris Self-Concept Scale (PHS), to assess the self-esteem of children with ADHD medicated with stimulants and those who were unmedicated.  Results showed that stimulants were associated with significantly higher self-esteem and children reported feeling more intelligent and more popular than unmedicated children with ADHD did.  Significant correlations indicated that higher doses were associated with higher levels of self-esteem.  The authors highlighted two possible interpretations for these results.  First, subjects reported higher self-esteem because they perceived that their behavior was under better control (and perhaps they were drawing less criticism from others).  Second, the dose-response correlations reflect stronger internal sensations caused by stimulants at higher doses and perhaps a greater hope for positive social outcomes.
      Kemptom, Vance, Maruff, Luk, Costin, and Pantelis (1999) attempted to measure  executive function in medicated and non-medicated children with ADHD by using a computerized battery.  Results from the study indicated that the unmedicated ADHD children showed impairment on tasks of executive function, including planning ability, movement time, attentional set shifting, and spatial working memory.  However, the group of medicated ADHD children showed no impairment on any of the executive function tasks, with the exception of poor performance on the spatial recognition memory task.  Results from this study are consistent with neuropsychological attributes of ADHD in specific regions of the brain.
      Thomson and Varley (1998) conducted a multivariate analysis with several predictor variables (age, gender, SES, family structure type, adoptive status, and neurological status) and response to medication in 336 children with ADHD from 3-16 years old.  All children underwent a 3-week, double blind trial of MPH and a placebo.  Three conditions were assigned to each child: a) 1 week of placebo, b) 1 week of .5 mg/kg daily of MPH in two divided doses, and c) 1 week of 1.0 mg/kg daily of MPH in two divided doses.  The CBCL and the Wechsler Intelligence Scale for Children (WISC-R) were completed before the drug trial period.  In addition, the Connors Abbreviated Symptom Questionnaires- Parent and Teacher forms and narratives regarding the child’s functioning were collected daily during the medication trial for the determination of response.  Results indicate that neurologic status, inattention, and overactivity were found to be most likely to predict good response to psychostimulants, whether rated by parents or teachers.  Although a number of variables predicted a positive psychostimulant response, the strength of the predictive associations suggests only a minimal clinical usefulness.

Cognitive-Behavioral Therapy for ADHD:

       A variety of cognitive-behavioral interventions have been used to treat ADHD in children. Ervin, Bankert, and DuPaul (1996) discuss several of these methods including: Cognitive-based interventions (i.e., self-instruction training and social problem-solving training), contingency-based interventions (i.e., self-monitoring, self-evaluation, self-reinforcement, and correspondence training), and cognitive-behavioral therapy (self-management) combined with other interventions.  The authors use empirical studies to examine the efficacy of these cognitive-behavioral interventions.
      Pelham, Wheeler, and Chronis (1998) evaluated psychosocial treatments for ADHD in children and adolescents using the Task Force Criteria.  The authors concluded that behavioral parent training and behavioral interventions in the classroom meet criteria for well-established treatments.  In comparison, cognitive interventions are not favored as they do not meet criteria for well-established treatments.
       The premise of many of these interventions is to develop self-control skills and reflective problem-solving strategies which are presumed to be deficient in children with ADHD.  However, when employed as a primary treatment, cognitive training has produced disappointing results and is recommended to be used only in combination with more effective interventions such as behavioral strategies and stimulant treatment (Hoza, Owens, & Pelham, 1999; Hinshaw, 1996, 2000).
 Hinshaw (2000) emphasizes that cognitive strategies must be combined with specific contingencies and extensive behavioral rehearsal, as the types of cognitive-mediational approaches that have been found to be effective with other child populations are clinically insufficient for treating children with ADHD.  One procedure that combines cognitive and behavioral strategies is the “Match Game” (Hinshaw, 1996) which provides explicit training in self-monitoring and self-evaluation, as youths with ADHD are “notorious for the inaccuracy of self-reports of their own behavior” (p. 295).  During the “Match Game”, youths are provided with behavioral contingencies and token rewards for correct self-evaluation of performance during a training session emphasizing a specific skill (e.g., cooperation).  The children discuss and compare their self-ratings with those of the adult trainer and receive extra points for accurate or matched ratings.  Over time, the frequency of the Match Game is reduced and the stakes are raised (e.g., no bonus points for poor behavior, regardless of match).  This procedure can be generalized to both home and school environments.
      After approximately 20 hours of group therapy in which Match Game procedures were taught and extensively rehearsed, boys were observed in classroom and playground settings.  No effect of this cognitive-behavioral strategy was seen in the classroom setting.  However, reinforced self-evaluation (the Match Game) was associated with fewer negative interactions than token reinforcement for cooperative social behavior alone.  However, optimal levels of social behavior were observed when medication was combined with reinforced self-evaluation.  In fact, only the combination of pharmacological and this cognitive-behavioral treatment brought levels of negative social interactions below the levels of comparison boys (Hinshaw, 1996).
      Cognitive-behavioral procedures have also demonstrated effectiveness when incorporated into anger management training.  Hinshaw (1996) discusses the findings of a study comparing the results of a cognitive-behavioral anger management curriculum with those of a control condition consisting of the instruction of cognitive procedures (discussions of empathy and perspective taking).  Subjects were also administered low doses of MPH or a placebo.  The anger management curriculum consisted of recognition of internal and external signals of incipient anger, the use of cognitive and behavioral strategies to manage the anger and prevent aggressive responses, and graduated rehearsal of selected strategies under increasingly realistic provocations from peers.  A unique feature of this curriculum was that each participant identified names and phrases that bother him to be used during the realistic peer provocations. The rehearsal-based cognitive-behavioral training was superior to the cognitive-only training on measures of coping responses, reduction of retaliation, and global self-control.  Furthermore, according to the results of post-treatment assessments conducted in the same groups in which the training took place, these CBT procedures proved superior to MPH with respect to outcomes related to anger control.  In a partial replication study conducted by the author, findings indicated that medication enhanced self-control and aggression reduction compared to placebo (Hinshaw, 1996).
      Mathes and Bender (1997) examined the effects of a specific cognitive-behavioral technique (self-monitoring) on children who were also receiving stimulant medications.  Participants were taught to self-monitor and record their behavior at random time intervals.  Self-monitoring was found to be very effective in increasing the attentional behavior of these students beyond the levels associated with medication alone (baseline condition).  The authors also found that some improvement in attending was maintained at the return to the baseline condition as a function of the cognitive nature of the training.  In addition, students’ general education teachers rated their attentiveness as improved, however, observations of on-task behavior in the regular setting were not made. A limitation of the study was that it was carried out in a special education classroom with only three students and needs to be replicated in a general education setting.
      Southam-Gerow, Henin, Chu, Marrs, and Kendall (1997) investigated cognitive-behavioral therapy (CBT) for ADHD and suggest that initial results appear to be promising for treating the cognitive and behavioral features of this disorder.  Multiple interventions including rewards, response-cost contingencies, modeling, homework, self-evaluation, perspective taking, and in-session as well as extra-session practice have been employed to teach youth with ADHD to delay impulsive actions and increase responsiveness to others.  While success has been modest, the authors conclude that medications continue to demonstrate superiority in overall effectiveness over CBT, even in studies in which CBT treatment fidelity was monitored.  The limited efficacy of CBT alone has led to combined trials with medication treatments, however, studies have not demonstrated the projected positive results.  The heterogeneity of ADHD populations and the extent of comorbidity suggest that single interventions may address only one feature of the disorder.  Additionally, the nature of the child’s specific attentional problems may impair their learning ability even in well-designed treatments.  The authors also suggest that developmental and familial factors should be considered when designing psychosocial treatments for this population.
      Kerns, Eso, and Thomson (1999) measured the efficacy of a child-oriented direct intervention method-Pay Attention!-for fourteen children (ages 7 to 11) diagnosed with ADHD.  Treatment and control groups were matched for age, sex, and medication status.  Measures included psychometrics, academic efficiency, and behavioral rating scales completed by parents and teachers.  Results indicated that the direct treatment approach was effective for improving performance on several psychometric measures of sustained, selective, and higher levels of attention.  Improvements were also noted in the treatment group on a measure of academic efficiency.

 Behavioral Therapy for ADHD:

      Schachar, Tannock, and Cunningham (1996) provide information regarding behavioral interventions for ADHD.  The authors refer to a combination of several factors which make comparisons with other intervention models a complicated task.  Included in this list are the wide range of target behaviors, the large number of people responsible for the implementation of a consistent behavior program, and the variety of behavioral approaches depending on the model of behavioral intervention (i.e., based on a cognitive-behavioral model or a social learning model).  Additionally, other factors such as the duration, frequency, strength, and setting under which these strategies are to be implemented may also influence outcomes.  Throughout the discussion, specific examples were given of  possible interventions for teachers, community-based interventions, cognitive-behavioral strategies to enhance self-control, social skills training, parenting skills, and the importance of family structure and functioning.  Limitations such as short-term effectiveness were discussed for many of the given strategies.
     Dawson (1997) provides a discussion of best practices in planning interventions for students with attentional disorders in the school setting, highlighting several empirically validated behavioral strategies.  Emphasis is placed upon clearly defining the skill deficits before planning interventions to address them.  ADHD children typically require more powerful and continuous reinforcers than non-ADHD children.  Extensive research has clearly identified that positive reinforcement is highly effective in addressing problem behaviors associated with attention disorders (e.g., sustained attention, time on task, response accuracy, disruptive behavior, social skills, etc.). As ADHD children tend to crave novelty and satiate quickly on specific reinforcers, a menu with a variety of highly desirable tangible rewards or activities has been found to be effective for motivating ADHD children.  Empirically-based strategies include: Token economies (immediate feedback is provided by rewarding tokens or points that can be redeemed for items from the reinforcement menu.), response cost (tokens or points are withdrawn when undesirable behaviors occur), and home-school report cards (with reinforcers contingent upon desirable performance of two to four target behaviors). Group rewards can also be incorporated into the token economy in order to enlist the help of the child’s peers. Particularly for young children who are aggressive and disruptive, time-out procedures (1-2 minute per year of the child’s age) can be very effective if a reinforcement system is already in place. Time-out procedures are not effective when they become a form of negative reinforcement, children are being sent out for behaviors that are not easily within their control (e.g. impulsive behaviors in response to provocation from another child), and/or the frequency of time-outs is not decreasing over time. Dawson also stresses the importance of educating teachers, parents and others working with the child about ADHD in order to clarify misperceptions about the disorder and prevent the implementation of ineffective behavior management programs.
     In a chapter reviewing prescriptive treatments for ADHD, Hoza, Owens, and Pelham (1999) address the obstacles of implementing behavioral treatments in less restrictive settings (e.g., contingency management in the regular education classroom or the home environment).  The authors point out that emphasis should be placed upon training teachers and parents as behavioral change agents to implement essentially the same behavior management strategies across settings so that there is a greater likelihood of cross-setting maintenance of treatment effects after termination. The authors recommend that a functional analysis be conducted across multiple settings prior to beginning treatment in order to prioritize the two or three most debilitating functional problems for intervention.  Progress should be monitored with a standard behavioral procedure such as a daily report card or a point system.  Necessary treatment changes should be made on when an intervention is not resulting in sufficient progress.  The assistance of a trained behavioral therapist may be required to increase the potency of behavioral interventions.  The authors also review empirical studies indicating that “less deterioration of behavior occurs with the withdrawal of negative consequences (e.g., during fading of response cost procedures), than during withdrawal of rewards.  Thus, response cost procedures may be considered an important component of treatment for ADHD children” (p. 68).
Hinshaw, Klein, and Abikoff (1998) propose that the most effective treatments of ADHD are generally behavioral approaches in combination with medication.  Their argument includes a presentation of the documented short-term efficacy of medication treatments.  In addition to describing studies of nonpharmacological/behavioral treatments, they also examine comparisons of behavioral and medication treatments and combined psychosocial-pharmacological intervention strategies.
      Iaboni, Douglas, and Ditto (1997) studied the psychophysiological responses of ADHD to reward and extinction by measuring heart rate and skin conductance levels.  Previous literature has linked heart rate during reward conditions to the Behavioral Activation System (BAS), while skin conductance level was thought related to the Behavioral Inhibition System (BIS).  Boys with ADHD habituated more quickly to the reward condition than did controls, and evidenced lower heart rates beyond the first trial.  The consistently lower heart rate of ADHD boys when reinforcement was reintroduced was taken as support for a somewhat weaker BAS.  ADHD boys also failed to show an increase in skin conductance level during extinction phase as was found with control children.  This finding supports the hypothesis that ADHD children have an underactive BIS.  The results of this study attest to the existence of a relationship between behavioral and psychophysiological functioning.  The authors noted that replication with a larger sample would be required to support the notion that ADHD students have weak Behavioral Activation and Behavioral Inhibition Systems.

Multimodal Treatments for ADHD:

     As appears to be emerging consensus in the field that no one treatment in itself will suffice to meet all of the needs of children and adolescents with ADHD, parent training has been suggested to be a valuable component of multimodal interventions (Anastopoulos, Barkley, & Shelton, 1996). Anastopoulos, Barkley, and Shelton (1996) present the findings of family-based psychosocial interventions designed to address the needs of children and adolescents with ADHD and their parents.  A study evaluating the effectiveness parent training program for school-aged children compared the results of a behavioral parent training group (PT) and a wait list control condition given information about alternative ADHD treatments.  Parent training consisted of ten sessions focusing on behavioral procedures targeting child noncompliance and primary ADHD symptomatology.  The program also included a parent counseling component.  The PT group parents reported improvements in the overall severity of their child’s ADHD symptomatology, a reduction in parental stress, and increased parental self-esteem relative to the parents in the waiting list condition.  However, there were no significant improvements reported with respect to parent-reported levels of personal distress and marital dissatisfaction.  Changes were maintained at two month follow-up and did not appear to be affected by the child’s medication status or stressful life events.
     Anastopoulos, Barkley, and Shelton (1996) also described the outcomes of a separate family-based intervention designed to specifically target parent-adolescent conflict.  The participants were assigned to one of three family-based psychosocial treatment conditions: Problem-solving communication training (PSCT), a developmentally appropriate version of the PT program discussed previously entitled Behavior Management Training (BMT), or structural family therapy (SFT).  This was the first time that these treatments had been empirically tested with an adolescent population.  Study data, when analyzed at a group level, revealed that all three treatment conditions produced significant improvements in several areas of family functioning including: Fewer conflicts, less anger intensity during conflict discussions, more effective communication immediately following treatment, less adolescent internalizing symptomatology, and lower levels of maternal depression. However, there were no statistically significant differences across the three groups.  All of these changes were maintained three months after treatment.
     Dunne, Arnold, Benson, and Bernet (1997) discussed a variety of treatment options for ADHD.  In considering various treatment options, the common means of treatment delivery and the positive and negative aspects of each treatment model were presented based on empirical evidence found under each model.  According to the authors, “comorbidity, specific target symptoms, and the strengths and weaknesses of the patient, family, school, and community” must be considered when selecting treatment strategies.  Furthermore, the developmental stage of the client must also be taken into account.  Intervention strategies presented in this article included psychoeducational treatment, pharmacotherapy, and psychosocial interventions.  With respect to psychoeducational treatment, the disbursement of information is considered common practice although individual and parent counseling has also been utilized under this domain.  The use of stimulants was given as the most popular means of pharmacotherapy although other medications such as Bupropion and Tricyclic Antidepressants have also been used.  Possible side effects and typical characteristics associated with the most common medications were given as key factors for consideration.  From a psychosocial standpoint, popular strategies included behavior modification, behavioral techniques used within school settings, parent training, family therapy, and individual psychotherapy.
      Abikoff and Hechtman (1996) implemented a multimodal treatment program for children with ADHD that entails the use of stimulant medication, academic study skills training, remedial tutoring as needed, individual psychotherapy, social skills training, parent management training, and strategies providing home-based reinforcements for school behavior and performance.  Research evaluation has examined children receiving this battery of treatments and compared them with a convention stimulant treatment group (CTG) and an attention control group (ACG).  These studies have helped to clarify the additive effects of specific behavioral and psychosocial treatments, over and above the effects of attention (ACG) or medication alone (CTG).
      Arnold, Abikoff, Cantwell, and Conners (1997) highlighted a two-year study in progress which is investigating the effectiveness of four different “designs” of intervention strategies for children diagnosed with ADHD.  Specifically, the four “designs” are: 1) medication only, 2) psychosocial treatment only, 3) combination of medication and psychosocial treatments, and 4) a control group receiving a mixture of treatments available in their respective communities.  This report was intended to address some methodological concerns and provide a rationale for certain choices made for this investigation.  The need to address the viewpoints of both clinicians and investigators was highly stressed in this report.
      DuPaul, Eckert, and McGoey (1997) discuss popular myths regarding the treatment of ADHD as well as offer important factors to consider when planning treatment.  The specific myths that were addressed include: 1) the necessity of medication because of the presumed neurobiological basis of the disorder, 2) token reinforcement and response cost systems as integral strategies for all children with ADHD, 3) the need for continuous reinforcement, 4) the need to train children with ADHD to regulate and manage their own behavior, and 5) that all children with ADHD should be placed in special education.  According to these authors, these beliefs are erroneous because of the heterogeneity of children receiving a diagnosis of ADHD.  In response to the claims, the authors call for a thorough understanding of behavior from a functional perspective as a pre-requisite to intervention development.  In their view, externalizing behavior can serve one of several purposes.  First, it is used as a means to avoid/escape task demands.  Second, inappropriate classroom behavior can be utilized to attract attention either from adults or from peers.  At times, these behaviors may also be employed to obtain tangible outcomes.  Finally, it was hypothesized that these behaviors may be used for automatic reinforcement.  In any case, an understanding of the antecedents and consequences of behavior is necessary prior to the determination of specific strategies to target symptoms.
     Hinshaw (2000) discusses the preliminary findings from the NIMH Multimodal Treatment Study of Children with ADHD (MTA).  The MTA is the largest randomized clinical trial ever conducted for a childhood psychiatric disorder. There are six participating sites in the United Sates and one in Canada evaluating a total subject pool of 579 children (ages 7-10) diagnosed with the Combined Type of ADHD. The long-term treatment lasted for a period of fourteen months.  Subjects were randomly assigned to one of four groups: 1) A Community Care (CC) control group that was referred to community mental health resources, 2) a group that received medication alone (MED), 3) a group that received a psychosocial treatment program based on behavioral therapy methods previously found to be effective with ADHD children (BEH), 4) and a combination group (COMB) that received a combination of the BEH and MED treatment procedures. The psychosocial treatments received by the BEH and the COMB groups included: An intensive combination of clinical behavior therapy (more than 35 parent training sessions paired with regular teacher consultation) and direct contingency management (an eight-week, all-day intensive summer school program based primarily on Pelham’s summer school treatment program (STP) (Pelham & Hoza, 1996)), and a paraprofessional aide in the child’s classroom).
     Group averages reveal that the combined treatment (COMB) was equivalent to the MED treatment with respect to reducing ADHD symptomatology and associated disruptive behaviors as well as increasing parent and peer indicators of social skills. However, comorbid internalizing features, parent-child relations, and teacher-appraised indicators of social skills responded optimally to the combination (COMB) treatment. The COMB and MED treatment groups outperformed the BEH and CC groups (the BEH and CC groups did not differ significantly from one another). In addition, further analyses suggest that, even for core ADHD symptomatology, combined treatment was more likely to produce excellent clinical response than medication alone (MED).  The exceptions to this general trend were subjects who possessed comorbid anxiety disorders.  These children performed equivalently in the behavior therapy (BEH), medication-only (MED), and combined (COMB) treatment conditions. As anxious and non-anxious subjects responded similarly to medication, the moderator effect was specific to the behavioral intervention.

Social Skills Treatment for ADHD:

     Hinshaw (2000) discusses the importance of the consistency of behavioral goals across the diverse settings of the ADHD child’s life, citing the social skills curriculum of Pfiffner and McBurnett (1997) as an example of an intervention providing for just such coordination.  Furthermore, Pfiffner and McBurnett’s social skills curriculum is described as exemplifying “an integrated cognitive-behavioral intervention based on a clear contingency management system” (p. 107).  Behavioral strategies incorporated into the curriculum include modeling, rehearsal (e.g., a free play module during which children practice skills and receive prompting and feedback), a reward system (tangible reinforcers and child-selected activities), response-cost, and time-outs.
     Pfiffner and McBurnett (1997) investigated the effectiveness of their brief social skills training (SST) on externalizing behaviors for children with ADHD. Twenty-seven children were randomly assigned to either SST with parent-mediated generalization (SST-PG), child-only SST, or a wait-list control group. The SST consisted of 8 group sessions in which skill modules were taught sequentially.  The goals of improving relationships with peers and adults were addressed through (1) remediating skills knowledge deficits, (2) remediating skills performance deficits, (3) fostering the child’s recognition of verbal and nonverbal cues, (4) teaching adaptive responding to new problem situations that arise, and (5) promoting generalization.  The parents of children in the SST-PG group simultaneously participated in generalization training with the objective of supporting their children's transfer of skills. Study findings revealed significant improvement in children's skill knowledge and in parent reports of social skills and disruptive behavior.  These treatment effects occurred for both treatment groups relative to the wait-list control group and were maintained at a 4-month follow-up. Furthermore, although only moderate generalizations were made to the school setting, those parents who were included as an additional component were more likely to generalize learned behaviors to the school environment.  In explaining the positive effects of SST found in this program, the authors offered several features, namely a stimulating and positively reinforcing curriculum and experienced, well-trained therapists, as critical factors contributing to the success.
     Sheridan, Dee, Morgan, McCormick, and Walker (1997) implemented a multimethod intervention for social skills deficits for children with ADHD and their parents.  Five boys (ages 8-10) with ADHD, all of whom were taking stimulant medication, participated in ten weekly sessions focusing on the target skills of social entry, maintaining interactions, and solving problems.  A separate parent group met simultaneously in which parents were taught the skills of debriefing, problem solving, and goal setting in order to assist their children with their social behavior. Despite inconsistencies across subjects, observations revealed that children and parents made positive mean increases in their use of targeted skills with the onset of treatment.  Furthermore, the children reported improvements of one standard deviation or more on self-report social skills ratings scales and both parent and teacher reports indicated improvement in the majority of subject areas.  The authors describe their study as representing “an initial attempt to investigate the effects of a combined medication/social skills intervention model for children with ADHD and their parents” (p. 224).  The authors suggest that these findings indicate “that parents can help support their child’s social skills and enhance their entry, maintenance, and problem-solving skills in the real world” (p. 223).
     Frankel, Myatt, Cantwell, and Feinberg (1997) examined the generalization of an outpatient social skills training program where parents were trained in skills relevant to their child's social adjustment.  Thirty-five children (aged 6.9-12.9 years) with ADHD and fourteen children without ADHD participated in 12 sessions of treatment (treatment group). Outcomes were compared with twelve children with ADHD and twelve children without ADHD who were on a waiting list for treatment (waitlist group). In addition, nineteen subjects with oppositional defiant disorder (ODD) were in the treatment group and five were on the waiting list.  Stimulant medication was prescribed for all children with ADHD.  Results showed that subjects with ADHD showed improvement comparable with that of subjects without ADHD on all teacher and parent-reported measures of peer adjustment and social skills, except teacher-reported withdrawal. Subjects with ODD had outcomes comparable with that of subjects without ODD. The average treatment group subject was better off than 83.4 percent of waiting list subjects on outcome measures.  These results suggest that subjects with ADHD benefit from a combination of social skills training for themselves, collateral training for their parents, and the use of stimulant medication.
      Colton and Sheridan (1998) present the use of conjoint behavioral consultation (CBC) as a model to join parents and educators in the shared development and implementation of interventions for students. A behavioral social skills intervention was delivered in the context of CBC to enhance the cooperative peer interactions of three boys (aged 8-9 years) diagnosed with ADHD.  A multiple probe design across participants was used.  The mothers and teachers of the boys served as consultants to the study.  Observational data indicated that the behavioral social skills intervention implemented within the context of CBC was related to increases in positive, cooperative interactions with peers.  Overall, positive changes were noted from pretreatment to posttreatment administrations of the Social Skills Rating System (F. M. Gresham & S.N. Elliott, 1990).  Measures of treatment acceptability, treatment integrity, and social validity also yielded positive results.  These findings provide evidence that the use of CBC can be a useful means of joining parents and teachers in the delivery of effective behavioral interventions.

Alternative Therapies for ADHD:

      The heterogeneity of ADHD as well as the unknown etiology of the disorder has created a number of treatment options for one to consider. More traditional therapies for children, such as play therapy, have not been demonstrated to be effective in the treatment of ADHD (Hoza, Owens, Pelham, 1999). The use of alternative therapies have had a long history in the treatment of ADHD, although the empirical evidence regarding these interventions have not yielded strong positive results.  Among these alternative therapies are nutritional supplements, dietary replacement, and neurofeedback procedures.
      Neurofeedback (or EEG training) is best considered as a brain exercise that over time teaches the child’s brain improved skills of managing attention, arousal (level of excitability), and affective or emotional state (Othmer, 1997).  This training rewards the child for changing brainwave activity toward what is more characteristic of a functional brain by challenging the child’s brain to self-adapt to a more functional state.  Kaiser and Othmer conducted a study in 1997 to demonstrate the efficacy of neurofeedback training in treating ADHD.  Significant improvement was found for measures of inattention, impulse control, and consistency of response after approximately twenty training sessions.  More than three-quarters of all subjects in deficit improved on one or more measures, a response rate comparable with psychostimulant therapy for ADHD.
 

II. DEVELOPMENTAL PERSPECTIVE

     Given the heterogeneous nature of ADHD symptomatology and the variety of causal mechanisms that have been postulated, it is important to consider the specific nature of the ADHD symptoms as well as the theoretical basis for the focus of intervention.  Many factors have been associated with the manifestation of ADHD behaviors, therefore no one specific treatment is likely to be effective across individuals and developmental periods. Pharmacological interventions have been shown to be effective for the improvement of functioning in the short-term but are insufficient for  addressing the long-term social and academic features of the disorder.  Likewise, behavioral treatments have been effective in producing specific behavior change in the short-term, but maintenance and generalization in the absence of associated contingencies has proven problematic.  Cognitive and cognitive-behavioral strategies address the executive and metacognitive aspects of the disorder which are thought to be related to inattention and distractibility, with some improvement in academic functioning (task completion) demonstrated.
Consideration of the child’s developmental level is important for treatment methods aimed at the cognitive domain of a child with ADHD. For example, Hinshaw (1996) described the saliency of developmental issues in an anger management curriculum employing cognitive-behavioral strategies. Younger subjects were taught to use more overt behavioral strategies (e.g., walk away) to resist provocation while preadolescent children are encouraged to use self-talk and other mediational strategies.
Several authors have suggested that ADHD children have developmental “lag” and perform at a level approximately two years behind their age-matched cohorts (Kempton, Vance, Maruff, Luk, Costin, & Pantelis, 1999).  Hinshaw (2000) hypothesizes that the general ineffectiveness of cognitive strategies with ADHD, in contrast to the demonstrated efficacy of cognitive interventions with other disorders, is due to the observation that “youth with this disorder continue to function, verbally and emotionally, at a level younger than their chronological years” (p. 116).  Furthermore, the core deficit of ADHD may occur “pre-verbally,” rendering approaches based upon verbal mediation to be ineffective for treating the underlying mechanism of the disorder (Hinshaw, 2000).
     There is a paucity of literature with respect to treatments that consider developmental trajectories. It is becoming increasingly apparent that the expression of ADHD symptomatology may change throughout development.  For example, a high activity level combined with aggressive tendencies are hallmarks of ADHD diagnosed in preschoolers, which may warrant behavioral and family interventions.  Difficulty in diagnosing ADHD in very young children may result in adverse treatment methods.  The DSM-IV cautions that making an ADHD diagnosis in the early years of childhood is problematic; not all infants and toddlers with a high activity level and aggressive behaviors meet the criteria for ADHD at a later age.  Diagnostic categories specifically designed for this age group are described in Zero to Three: Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood (Zero to Three/National Center for Clinical Infant Programs, 1994) and in The Classification of Child and Adolescent Mental Diagnoses in Primary Care (Rappley, Mullan, Alvarez, Eneli, Wang, & Gardiner, 1999).  Proper diagnosis may have important implications for treatment issues, especially with the use of psychotropic medications where long-term side effects are currently unknown.
     During latency age, success in school is the primary developmental task, and it is at this stage that inattentive-distractible features of the disorder become salient, as these clearly impair cognitive and academic functioning.  Here, medication and cognitive-behavioral therapy may be most efficacious, provided that aggressive behaviors are absent.  In the adolescent and early adult years, continued academic and social difficulties persist for the youth with ADHD.  Often, medication is found to be less desirable, and emphasis on self-monitoring with added training in social skills may be beneficial.  Young adults may need educational and vocational counseling as means to manage their disorder.
Developmental pathways are determined to a great extent by familial and ecological factors.  Parenting style influences the expression of ADHD at all levels of development.  Chaotic homes, dysfunctional communication styles, poor or inappropriate modeling, and parental psychopathology interact with ADHD behaviors and may exacerbate their expression.  Family stressors including poverty and unsafe neighborhoods may reinforce maladaptive behavioral development.  Furthermore, ADHD as a diagnosis may represent the extremes of impulsivity and overactivity on a behavioral continuum, with children who fall short of meeting diagnostic criteria still in need of preventive intervention.  In addition, comorbidity with Oppositional Defiant Disorder, Conduct Disorder, Learning Disabilities and language disorders are common, and complicate the theoretical and practical selection of intervention strategies.
 

III. OPTIMAL TREATMENT

     Based on a review of the current literature regarding treatment for ADHD, a multimodal approach seems the most effective treatment for the following reasons.  First, the consideration of a wide array of factors, including comorbidity, target symptoms, individual characteristics, and environmental variables, are undoubtedly crucial elements in any discussion of treatment selection. A multimodal approach, which takes a variety of factors into account, would appear to be the most comprehensive treatment in this regard as well as the most likely to result in treatment effects being generalized across the diverse settings of the youth’s life. Hinshaw (2000) stresses the importance of communication and coordination amongst service providers: “If services are fragmented, and if educators, medical personnel, psychologists, and paraprofessionals do not coordinate efforts, it is virtually a guarantee that intervention efforts will be limited and spotty” (p. 106).
     Second, the multimodal approach appears to be the optimal treatment for ADHD because of the inconsistent and limited efficacy of any single treatment modality.  Based on reports from various investigators in the field, different treatment strategies have apparently encountered various degrees of success which, again, points to the heterogeneity of this particular disorder.
     Finally, consistent with the developmental psychopathology perspective and the transactional framework, consideration of the interactions between various factors over time can best be viewed from a multimodal perspective.  More specifically, through this approach, treatment can be tailored to the specific needs of individuals based upon their unique developmental pathways. Ideally, an extensive behavioral assessment and functional skills analysis should be conducted in order to select target behaviors to address in treatment.  This individualized approach is more likely to meet the youth’s specific needs than participation in interventions that are designed to address ADHD behaviors reported in the research literature (Hoza, Owens, & Pelham, 1999; Sheridan, Dee, Morgan, McCormick, & Walker, 1997).  Furthermore, researchers have consistently identified the need for on-going treatment for this often chronic disorder (Hinshaw, 2000; Sheridan, Dee, Morgan, McCormick, & Walker, 1997).  Thus, the effects of many interventions may be limited due to their short-term nature.
     Barkley (1997) identifies the setting as a critical factor in the treatment method for ADHD.  He points out that the most useful treatment approaches will be those that take place in natural settings at the point of performance where the desired behavior is to occur.  Examples of such treatments would be behavior modification programs that aim to restructure the natural setting and its contingencies so as to achieve a change in the desired behavior and maintain that desired behavior over time.
 

IV. CONCLUSION

     The selection of an optimal treatment for children with ADHD is made more complex by the fact that there is not a definitive cause for this particular disorder. Various treatment strategies, based on divergent causal attributions of ADHD, have been utilized. However, despite varying degrees of success, no single treatment has been shown to be
effective for all children with ADHD.  From a developmental psychopathology perspective, this is supportive of the idea of equifinality, meaning that various developmental pathways can result in a singular outcome.  Therefore, a multimodal approach, which accounts for different factors over time, would appear to be the most appropriate treatment at this time.
      ADHD is a complex and heterogeneous constellation of behaviors which impacts  the socialization, cognition, and self-perception of the individuals affected by it.  Appropriate diagnosis and treatment of ADHD cannot take place without "some overarching conceptions about the nature of the disorder and…without consideration of key psychometric, developmental, and theoretical issues" (Hinshaw, 1994).  Clearly, specific underlying causes for ADHD have been moved in the direction of identifying two core mechanisms of ADHD: Inattention and Impulsivity.  Inattention refers to the cognitive components of difficulty initiating and maintaining interest in tasks that are of  low reinforcement value.  Furthermore, disorganization is a secondary feature of the Inattentive Type.  Impulsivity refers mainly to the problems of motoric overactivity and behavioral disinhibition which are the salient characteristics of the disorder.
     It is important for parents and professionals to be informed about the potential developmental trajectories related to ADHD.  According to the transactional model, genetic, biological, cognitive, familial, and social-ecological factors interact in both predictable and unique ways to affect developmental trajectories.  Antisocial behavior and substance abuse develop in one-fourth of adolescents and young adults diagnosed with ADHD (Hinshaw, 1994), while nearly one third show increased resiliency and become healthy, high-functioning adults (Barkley, 1997).  The risk for deleterious versus positive outcomes appears to be mediated most clearly by familial, social, and ecological factors which are related to one's developmental course.  In diagnosing ADHD, the DSM-IV-TR requires that some symptoms of ADHD be present before age 7, indicating the developmental path of this disorder.  In addition, the behaviors must be present in two or more settings (such as home and school), in support of an ecological view.  Further research needs to be undertaken, however, on the longitudinal course of the disorder, as the salient features appear to vary across the lifespan trajectory.

V. REFERENCES

    Abikoff, H.B., & Hechtman, L. (1996). Multimodal therapy and stimulants in the treatment of children with attention deficit hyperactivity disorder. In E.D. Hibbs and P.S. Jensen (Eds.), Psychosocial treatments for Child and Adolescent Disorders: Empirically based strategies for clinical practice. Washington, DC: American Psychological Association.
    American Psychiatric Association (2000).  Diagnostic and statistical manual of mental disorders (4th ed.).  Washington, DC: Author.
    Anastopoulos, A. D., Barkley, R. A., & Sheldon, T. L. (1996).  Family-based treatment: Psychosocial intervention for children and adolescents with Attention Deficit Hyperactivity Disorder.  In E. D. Hibbs &  P. S. Jensen (eds.), Child and Adolescent Disorders: Empirically Based Strategies for Clinical Practice  (pp. 267-284). Washington, DC: American Psychological Association.
     Arnold, L.E., Abikoff, H.B., Cantwell, D.P., & Connors, C.K. (1997). National Institute of Mental Health Collaborative Multimodal Treatment Study of Children with ADHD (the MTA): Design challenges and choices. Archives of General Psychiatry, 54, 865-870.
     Barabasz, M. & Barabasz, A. (1996). Attention deficit disorder: Diagnosis, etiology, and treatment.  Child Study Journal, 26(1), 1-37.
     Barkley, R. A., Connor, D. F., & Kwasnik, D. (2000).  Challenges to determining adolescent medication response in an outpatient clinical setting: Comparing Adderall and methylphenidate for ADHD.  Journal of Attention Disorders, 4(2), 102-113.
     Barkley, R.A. (1997). Biological etiologies associated with ADHD. In R.A. Barkley, ADHD and the nature of self-control. (29-46). New York: Guilford Press.
     Barkley, R.A. (1997). Understanding ADHD and Self-Control: Social and Clinical Implications. In ADHD and the Nature of Self-Control. New York, NY: Guilford Press.
     Biederman, J., & Spencer, T. (1999).  Attention-Deficit/Hyperactivity Disorder (ADHD) as a noradrenergic disorder.  Biological Psychiatry, 46, 1234-1242.
     Bird, H.R., Gould, M.S., & Staghezza, B.M. (1993).  Patterns of diagnostic comorbidity in a community sample of children aged 9 through 16 years.  Journal of the American Academy of Child and Adolescent Psychiatry, 32, 361-368.
     Botting, N., Powls, A., Cooke, R.W.I., & Marlow, N. (1997). Attention deficit hyperactivity disorders and other psychiatric outcomes in very low birthweight children at 12 years.  Journal of Child Psychology and Psychiatry, 38(8), 931-941.
     Boyle, M.H., Offord, D.R., Racine, Y.A., & Szatmari, P. (1996). Interviews versus checklists: Adequacy for classifying childhood psychiatric disorder based on adolescent reports. International Journal of Methods in Psychiatric Research 6(4), 309-319.
     Brown, M. B. (2000).  Diagnosis and treatment of children and adolescents with Attention-Deficit/Hyperactivity Disorder.  Journal of Counseling and Development, 78, 195-201.
     Carte, E.T., Nigg, J.T., & Hinshaw, S.P. (1996). Neuropsychological functioning, motor speed, and language processing in boys with and without ADHD.  Journal of Abnormal Child Psychology, 24(4), 481-489.
     Chae, P. K. (1999).  Correlation study between WISC-III scores and TOVA performance.  Psychology in the Schools, 36(3), 179-184.
     Colton, D.L., & Sheridan, S.M. (1998). Conjoint behavioral consultation and social skills training: Enhancing the play behaviors of boys with attention deficit hyperactivity disorder. Journal of Educational & Psychological Consultation, 9(1), 3-28.
     Comings, D. E. (1997).  Genetic aspects of childhood behavioral disorders.  Child Psychiatry and Human Development, 27(3), 139-150.
      Connors, C.K., Sitareios, G., Parker, J.D., & Epstein, J.N. (1998). The revised Connors Parent Rating Scale (CPRS-R): Factor structure, reliability, and criterion validity. Journal of Abnormal Child Psychology, 26(4), 257-268.
      Corkum, P.V., & Siegel, L.S. (1993). Is the Continuous Performance Task a valuable research tool for use with children with Attention Deficit Hyperactivity Disorder? Journal of Child Psychology & Psychiatry & Allied Disciplines, 34(7), 1217-1239.
      Cornett-Ruiz, S., & Hendricks, B. (1993).  Effects of labeling and ADHD behaviors on peer and teacher judgements.  Journal of Educational Research, 86(6), 349-355.
     Costantino, G., Colon-Malgady, G., Malgady, R G., & Perez, A. (1991). Assessment of attention deficit disorder using a thematic apperception technique. Journal of Personality Assessment, 57(1), 87-95.
     Dawson, M. M. (1997).  Best practices in planning interventions for students with attention disorders.  In D. L. Smallwood (Ed.), Attention Disorders in Children: Resources for School Psychologists (pp. 123-134).  Bethesda, Maryland: National Association of School Psychologists.
     Dunne, J.E., Arnold, V., Benson, S., & Bernet, W. (1997). Summary of the practice parameters for the assessment and treatment of children, adolescents, and adults with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 1311-1318.
     Ervin, R.A., Bankert, C.L., DuPaul, G.J. (1996). Treatment of attention-deficit/hyperactivity disorder. In M.A. Reinecke, F.M.  Dattilio, A. Freeman (Eds.). Cognitive Therapy with Children and Adolescents: A Casebook for Clinical Practice. New York, NY: Guilford Press.
      Faraone, S. V. (2000).  Genetics of childhood disorders: XX.  ADHD Part 4: Is ADHD genetically heterogeneous?  Journal of the American Academy of Child and Adolescent Psychiatry, 39(11), 1455-1461.
     Faraone, S.V., Biederman, J, & Monuteaux, M. (2000).  Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder.  Genet Epidemiol, 18, 1-16.
     Fisher, M., Barkley, R.A., Edelbrock, C.S., & Smallish, L. (1990). The adolescent outcome of hyperactive children diagnosed by research criteria: Academic, attentional, and neuropsychological status. Journal of Consulting & Clinical Psychology, 58(5), 580-588.
     Forbes, G.B. (1998). Clinical utility of the Test of Variables of Attention (TOVA) in the diagnosis of attention-deficit/hyperactivity disorder. Journal of Clinical Psychology, 54(4), 461-476.
     Frankel, F., Myatt, R., Cantwell, D.P., & Feinberg, D.T. (1997). Parent-assisted transfer of children’s social skills training: Effects on children with and without attention-deficit hyperactivity disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 36(8), 1056-1064.
     Frankel, F., Cantwell, D.P., Myatt, R., & Feinberg, D.T. (1999). Do Stimulants Improve Self-Esteem in Children with ADHD and Peer Problems? Journal of Child and Adolescent Psychopharmacology, 9(3), 185-194.
     Frazier, M.R., & Merrell, K.W. (1997). Issues in behavioral treatment of attention-deficity/hyperactivity disorder. Education & Treatment of Children, 20(4), 441-461.
     Gingerich, K.L., Turnock, P., Litfin, J.K., & Rosen, L.A. (1998).  Diversity and attention deficit hyperactivity disorder.  Journal of Clinical Psychology, 54(4), 415-426.
     Glutting, J. J., Robins, P. M., & De Lancey, E. (1997).  Discriminant validity of test observations for children with Attention Deficit/Hyperactivity.  Journal of School Psychology, 35(4), 391-401.
     Handen, B.L., McAuliffe, S., Janosky, J., & Feldman, H. (1998). A playroom observation procedure to assess children with mental retardation and ADHD. Journal of Abnormal Child Psychology, 26(4), 269-277.
     Harvey, P. (1998). Parental employment and conduct problems among children with attention-deficit/hyperactivity disorder: an examination of child care workload and parenting well-being as mediating variables.  Journal of Social & Clinical Psychology, 17(4), 476-490.
     Hechtman, L. (1996). Families of children with attention deficit hyperactivity disorder: A review. Canadian Journal of Psychiatry, 41(6), 350-360.
      Hechtman, L. (2000).  Assessment and diagnosis of Attention-Deficit/Hyperactivity Disorder.  Child and Adolescent Psychiatric Clinics of North America, 9(3), 481-498.
     Hill, S. Y., Lowers, L., Locke-Wellman, J. (2000).  Maternal smoking and drinking during pregnancy and the risk for child and adolescent psychiatric disorders.  Journal of Studies on Alcohol, 61(5), 661-677.
     Hinshaw, S.P. (1994). Attention Deficits and Hyperactivity in Children. Thousand Oaks, CA: Sage Publications.
     Hinshaw, S. P. (1996).  Enhancing social competence: Integrating self-management strategies with behavioral procedures for children with ADHD.  In E. D. Hibbs &  P. S. Jensen (eds.), Child and Adolescent Disorders: Empirically Based Strategies for Clinical Practice  (pp. 285-310). Washington, DC: American Psychological Association.
     Hinshaw, S. P. (2000).  Attention-Deficit/Hyperactivity Disorder: The search for viable treatments.  In P.C. Kendall (Ed.), Child and Adolescent Therapy: Cognitive-Behavioral Procedures (2nd ed., pp. 88-128).  New York: The Guilford Press.
     Hinshaw, S.P., Klein, R.G., & Abikoff, H. (1998). Childhood attention deficit hyperactivity disorder: Nonpharmacological and combination treatments. In P.E. Nathan, & J.M. Gorman et.al. (Eds.) A Guide To Treatments that Work. New York, NY: Oxford University Press.
     Hinshaw, S.P., Zupan, B.A., Simmel, C., Nigg, J.T., & Melnick, S.  (1997).  Peer Status in boys with and without Attention-deficit Hyperactivity Disorder: Predictions from overt and covert antisocial behavior, social isolation, and authoritative parenting beliefs. Child Development, 68(5), 880-896.
     Holland, M.L., Gimpel, G.A., & Merrell, K.W. (1998). Innovations in Assessing ADHD: Development, Psychometric Properties, and Factor Structure of the ADHD Symptoms Rating Scale (ADHD-SRS). Journal of Psychopathology and Behavioral Assessment, 20(4), 307-333.
     Horrigan, J.P. (1999). Nutritional Supplements in ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 38(10), 1209-1211.
     Hoza, B., Owens, J. S., & Pelham, W. E., Jr. (1999).  Attention-Deficit/Hyperactivity Disorder.  In R. T. Ammerman, M.  Hersen, & C. G. Last (Eds.), Handbook of Prescriptive Treatments for Children and Adolescents (2nd ed., pp. 63-83).  Boston: Allyn and Bacon.
     Iaboni, F., Douglas, V.I., & Ditto, B. (1997). Psychophysiological response of ADHD children to reward and extinction. Psychophysiology, 34, 116-123.
     Inoue, K., Nadaoka, T., Oihi, A., Morioka, Y., Totsuka, S., Kanbayashi, Y., & Hukui, T. (1998). Clinical Evaluation of Attention-Deficit Hyperactivity Disorder by Objective Quantitative Measures. Child Psychiatry and Human Development, 28(3), 179-187.
     Jensen, P. S., Kettle, L., Roper, M. T., Sloan, M. T., Dulcan, M. K., Hoven, C., Bird, H. R., Bauermeister, J. J., & Payne, J. D. (1999).  Are stimulants overprescribed?  Treatment of ADHD in four U.S. communities.  Journal of the American Academy of Child and Adolescent Psychiatry, 38(7), 797-805.
     Johnston, C. (1996). Parent characteristics and parent-child interactions in families of nonproblem children and ADHD children with higher and lower levels of oppositional-defiant behavior.  Journal of Abnormal Child Psychology, 24(1), 85-104.
     Johnston, C. & Freeman, W. (1997). Attributions for child behavior in parents of children without behavior disorders and children with attention deficit-hyperactivity disorder.  Journal of Consulting and Clinical Psychology, 65(4), 636-645.
     Kaiser, D.A. & Othmer, S. (1997).  Efficacy of SMR-Beta Neurofeedback for Attentional Processes. EEG Spectrum.
     Kamphaus, R W., Reynolds, C. R., & Hatcher, N. M. (1999).  Treatment planning and evaluation with the BASC: The Behavior Assessent System for Children.  In, M. E. Maruish (Ed.), The use of psychological testing for treatment planning and outcome assessment  (p. 563-597). Mahwah, N.J.: Lawrence Erlbaum Associates.
     Kempton, S., Vance, A., Maruff, P., Luk, E., Costin, J., & Pantelis, C. (1999).  Executive function and attention deficit hyperactivity disorder: stimulant medication and better executive function performance in children.  Psychological Medicine, 29, 527-538.
     Kerns, K.A., Eso, K., & Thomson, J. (1999). Investigation of a Direct Intervention for Improving Attention in Young Children with ADHD. Developmental Neuropsychology,  16(2), 273-295.
     King, J.A., Barkley, R.A., & Barrett, S. (1998). Attention-deficit hyperactivity disorder and the stress response.  Biological Psychiatry, 44(1), 72-74.
     LeFever, G.B., Dawson, K.V., & Morrow, A.L. (1999). The Extent of Drug Therapy for Attention Deficit-Hyperactivity Disorder Among Children in Public Schools. American Journal of Public Health, 89(9), 1359-1364.
     Lett, N.J., & Kamphaus, R.W. (1997). Differential validity of the BASC Student Observation system and the BASC Teacher Rating Scale. Canadian Journal of School Psychology, 13(1), 1-14.
     Levy, T., Hay, D.A., McStephen, M., Wood, C., & Waldman, I. (1997). Attention deficit-hyperactivity disorder: A category or a continuum? Genetic analysis of a large-scale twin study. Journal of the American Academy of Child and Adolescent Psychiatry, 36, 737-744.
     Lin, C.C., Hsiao, C.K., & Chen, W.J. (1999). Development of sustained attention assessed using the Continuous Performance Test among children of 6-15 years of age. Journal of Abnormal Child Psychology, 5, 403-412.
     Manos, M.J., Short, E.J., & Findling, R.L. (1999). Differential Effectiveness of Methylphenidate and Adderall in School-Age Youths With Attention-Deficit/Hyperactivity Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 38(7), 813-819.
     Marks, D.J., Himselstein, J., Newcorn, J.H., & Halperin, J.M. (1999). Identification of ADHD subtypes using laboratory-based measures: A cluster analysis. Journal of Abnormal Child Psychology, 27(2), 167-175.
     Mathes, M.Y. & Bender, W.N. (1997). The effects of self-monitoring on children with attention-deficit/hyperactivity disorder who are receiving pharmacological interventions. Remedial and Special Education, 18(2), 121-128.
     Max, J.E., Arndt, S., Castillo, C.S., Bokura, H., R, D.A., Lindgren, S.A., Smith, W.L., Sato, Y., & Mattheis, P.J. (1998). Attention deficit hyperactivity symptomalogy after traumatic brain injury: A prospective study.  Journal of the American Academy of Child & Adolescent Psychiatry, 37(8), 841-847.
     Mayes, S. D., Calhoun, S. L., & Crowell, E. W. (2000).  Learning disabilities and ADHD: Overlapping spectrum disorders.  Journal of Learning Disabilities, 33(5), 417-424.
     McConaughy, S. H.; Achenbach, T. M. (1996).  Contributions of a child interview to multimethod assessment of children with EBD and LD. School Psychology Review, 25 (1), 24-39.
     McGee, R. A., Clark, S. E., & Symons, D. K. (2000).  Does the Connors’ Continuous Performance Test aid in ADHD diagnosis?  Journal of Abnormal Child Psychology, 28(5), 415-443.
     Milberger, S., Biederman, J., Faraone, S.V., Chen, L., & Others (1996). Is maternal smoking during pregnancy a risk factor for attention deficit hyperactivity disorder in children? American Journal of Psychiatry, 153 (9), 1138-1142.
     Milberger, S., Biederman, J., Faraone, S.V., & Guite, J. (1997). Pregnancy, delivery, and infancy complications and attention deficit hyperactivity disorder: Issues of gene-environment interaction.  Biological Psychiatry, 41(1), 65-75.
     Mirsky, A. F., Pascualvaca, D. M., Duncan, C. C., & French, L. M. (1999).  A model of attention and its relation to ADHD.  Mental Retardation and Developmental Disabilities Research Reviews, 5, 169-176.
     Murphy, K.R., & Gordon, M. (1998). Assessment of adults with ADHD. In R.A. Barkley (et.al., Eds.), Attention-Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment. (2nd edition). New York, NY: The Guilford Press. 345-369.
     Nadder, T. S., Silberg, J. L., Eaves, L. J., Maes, H. H.,  & Meyer, J. M. (1998).  Genetic effects on ADHD symptomalogy in 7- to 13-year?old twins: results from a telephone survey.  Behavior Genetics. 28(2), 83-99.
     Nigg, J.T. (1999).  The ADHD response-inhibition deficit as measured by the stop task: Replication with DSM-IV combined type, extension, and qualification.  Journal of Abnormal Child Psychology, 27 (5), 393-402.
    Nigg, J.T., & Hinshaw, S.P. (1998). Parent personality traits and psychopathology associated with antisocial behaviors in childhood attention-deficit hyperactivity disorder.  Journal of Child Psychology & Psychiatry & Allied Disciplines, 39 (2), 145-159.
     Nadder, T. S., Silberg, J. L., Eaves, L. J., Maes, H. H.,  & Meyer, J. M. (1998).  Genetic effects on ADHD symptomalogy in 7- to 13-year?old twins: results from a telephone survey.  Behavior Genetics. 28(2), 83-99.
     Nigg, J.T. (1999).  The ADHD response-inhibition deficit as measured by the stop task: Replication with DSM-IV combined type, extension, and qualification.  Journal of Abnormal Child Psychology, 27 (5), 393-402.
     Nigg, J.T., & Hinshaw, S.P. (1998). Parent personality traits and psychopathology associated with antisocial behaviors in childhood attention-deficit hyperactivity disorder.  Journal of Child Psychology & Psychiatry & Allied Disciplines, 39 (2), 145-159.
     Olson, S. (1996). Developmental perspectives.  In Sandberg (Ed.), Hyperactivity Disorders of Childhood. Cambridge: Cambridge University Press.
     Oosterlaan, J. & Sergeant, J.A. (1996). Inhibition in ADHD, aggressive, and anxious children: A biologically based model for child psychopathology. Journal of Abnormal Child Psychology, 24(1), 19-36.
     Parker, J.G., & Asher, S.R. (1987). Peer Relations and later personal adjustment. Are low accepted children at risk? Psychological Bulletin, 102, 357-389.
     Pelham, W. E., Jr., & Hoza, B. (1996).  Intensive Treatment: Summer Treatment Program for Children With ADHD.  In E. D. Hibbs &  P. S. Jensen (eds.), Child and Adolescent Disorders: Empirically Based Strategies for Clinical Practice  (pp. 311-340). Washington, DC: American Psychological Association.
     Pelham, W.E. Jr., Wheeler, T.B., & Chronis, A. (1998). Empirically supported psychosocial treatments for attention deficit hyperactivity disorder. Journal of Clinical Child Psychology, 27(2), 190-205.
     Pfiffner, L., & McBurnett, K. (1997). Social Skills Training With Parent Generalization: Treatment Effects for Children with Attention Deficit Disorder. Journal of Consulting and Clinical Psychology, 65, 749-757.
     Pfiffner, L.J., McBurnett, K., Lahey, B.B., Loeber, R. Green, S., Frick, P.J., & Rathouz, P.J. (1999).  Association of Parental Psychopathology to the Comorbid Disorders of Boys With Attention Deficit-Hyperactivity Disorder.  Journal of Consulting and Clinical Psychology, 67 (6), 881-893.
     Rappley, M.D., Mullan, P.B., Alvarez, F.J., Eneli, I.U., Wang, J., & Gardiner, J.C. (1999). Diagnosis of Attention-Deficit/Hyperactivity Disorder and Use of Psychotropic Medication in Very Young Children. Archives of Pediatrics & Adolescent Medicine, 153(10), 1039-1045.
     Rhee, S. H., Waldman, I. D., Hay, D. A., & Levy, F. (1999).  Sex differences in genetic and environmental influences on DSM-III-R Attention-Deficit/Hyperactivity Disorder.  Journal of Abnormal Psychology, 108(1), 24-41.
     Roberts, M., & DuPaul, G. (2000). Evaluating Medication Effects for Students with Attention Deficit/Hyperactivity. Communique, 28(6), 12-13.
     Russo, M.F., & Beidel, D.C. (1994). Comorbidity of childhood anxiety and externalizing disorders: Prevalence, associated characteristics, and validation issues.  Clinical Psychology Review, 14, 199-221.
     Sandberg, S., & Garralda, M.E. (1996). Psychosocial contributions.  In Sandberg (Ed.), Hyperactivity Disorders of Childhood. Cambridge: Cambridge University Press.
     Sameroff, A.J., & Chandler, M.J. (1975). Reproductive risk and the continuum of caretaking casualty.  In F.D. Horowitz, M. Hetherington, S. Scarr-Salapatek & G. Siegal (Eds.), Review of Child Developmental Research, Vol. 4. Chicago: University of Chicago Press.
     Sameroff, A.J., & Fiese, B. (1988). Conceptual issues in prevention.  Unpublished manuscript. Brown University: Providence, R.I. Schachar, R., Tannock, R., & Cunningham, C. (1996). Treatment. In Sandberg (Ed.), Hyperactivity Disorders of Childhood. Cambridge: Cambridge University Press.
     Schaughency, E.A., & Rothlind, J. (1991). Assessment and classification of attention-deficit hyperactivity disorder. School Psychology Review, 20, 187-202.
     Schwab-Stone, M., fisher, P., Piacetini, J., Shaffer, D., Davies, M., & Briggs, M. (1993). The Diagnostic Interview Schedule for Children. Revised Version (DISC-R): Test-Retest Reliability. Journal of the American Academy of Child and Adolescent Psychiatry, 32, 651-657.
     Seidman, L.J., Biederman, J., Faraone, S.V., Weber, W., & Oullette, C. (1997). Toward defining a neuropsychology of attention-deficit hyperactivity disorder: Performance of children and adolescents from a large clinically referred sample.  Journal of Consulting and Clinical Psychology, 65(1), 150-160.
     Sheppard, D. M., Bradshaw, J.L., Purcell, R., & Pantelis, C. (1999). Tourette’s and comorbid syndromes: Obsessive compulsive and attention deficit hyperactivity disorder. A common etiology? Clinical Psychology Review, 19 (5), 531-552.
     Sheridan, S. M., Dee, C. C., Morgan, J. C., McCormick, M. E., & Walker, D. (1997).  A multimethod intervention for social skills deficits in children with ADHD and their parents.  In D. L. Smallwood (Ed.), Attention Disorders in Children: Resources for School Psychologists (pp. 211-225).  Bethesda, Maryland: National Association of School Psychologists.
     Sherman, D. K., McGue, M. K. & Iacono, W. G. (1997).  Twin concordance for attention deficit hyperactivity disorder:  A comparison of teachers’ and mothers’ reports.  American Journal of Psychiatry, 15(4), 532-535.
     Silberstein, R.B., Farrow, M., Levy, F., Pipingas, A., Hay, D.A., & Jarman, F.C. (1998). Functional brain electrical activity mapping in boys with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 55(12), 1105-1112.
     Smith, S. R., Wingenfeld, S. A., Hilsenroth, M. J., Reddy, L. A., & LeBuffe, P. A. (2000).  The use of the Devereux Scales of Mental Disorders in the assessment of Attention-Deficit/Hyperactivity Disorder and Conduct Disorder.  Journal of Psychopathology and Behavioral Assessment, 22(3), 237-255.
     Southam-Gerow, M.A., Henin, A., Chu, B., Marrs, A., & Kendall, P.C. (1997). Cognitive-Behavioral therapy with children and adolescents. Child and Adolescent Psychiatric Clinics of North America,  6(1), 111-136.
     Sprich, S., Biederman, J., Crawford, M. H., Mundy, E., & Faraone, S. (2000).  Adoptive and biological families of children and adolescents with ADHD.  Journal of the American Academy of Child and Adolescent Psychiatry, 39(11), 1432-1143.
     Stein, M. A. (1999).  Unravelling sleep problems in treated and untreated children with ADHD.  Journal of Child and Adolescent Psychopharmacology, 9(3), 157-168.
    Swanson, J.M, Wigal, S., Greenhill, L.I., Browne, R., Waslik, B., Lerner, M., Williams, L., Flyn, D., Agler, D., Crowley, K., Finberg, E., Baren, M., & Cantwell, D.P. (1998). Analog classroom assessment of Adderall in children with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 519-526.
     Tannock, R. (1998). Attention Deficit Hyperactivity Disorder: Advances in Cogntive, Neurobiological, and Genetic Research.  Journal of Child Psychology and Psychiatry, 39(1), 65-99.
     Thomson, J.B., & Varley, C.K. (1998). Predictions of stimulant response in children with attention-deficit/hyperactivity disorder. Journal of Child & Adolescent Psychopharmacology, 8(2), 125-132.
     Vaughn, M.L., Riccio, C.A., Hynd, G.W., & Hall, J. (1997). Diagnosing ADHD (predominantly inattentive and combined type subtypes): Discriminant validity of the Behavior Assessment System for Children in the Achenbach Parent and Teacher Rating Scales. Journal of Clinical Child Psychology, 26(4), 349-357.
     Warner-Rogers, J., Taylor, A., & Seija Sandberg (2000).  Inattentive behavior in childhood: Epidemiology and implications for development.  Journal of Learning Disabilities, 33 (4), 520-536.
     Weinstein, C.S., Apfel, R.J., & Weinstein, S.R. (1998). Description of mothers with ADHD with children with ADHD.  Psychiatry: Interpersonal and Biological Processes, 61(1), 12-19.
     Weiss, G., & Hechtman, , L.T. (1993). Hyperactive children grown up. ADHD children, adolescents, and adults. (2nd ed.). New York, NY: Guilford Press.
     White, J. D. (1999).  Personality, temperament and ADHD: A review of the literature.  Personality and Individual Differences, 7, 589-598.
     Wolraich, M.L., Felice, M.E., & Drotar, D. (Eds.) (1996). The Classification of Child and Adolescent Mental Diagnoses in Primary Care. Elk Grove Village, Ill: American Academy of Pediatrics.
     Woodward, L., Dowdney, L. & Taylor, E. (1997). Child and family factors influencing the clinical referral of children with hyperactivity: A research note.  Journal of Child Psychology and Psychiatry, 38(4), 479-485.
     Zero to Three/National Center for Clinical Infant Programs. (1994).  Zero to Three: Diagnostic Classification of Mental Health and Developmental Disorders of Infancy and Early Childhood. Washington, DC: National Center for Clinical Infant Programs.
 

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